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Bicyclomycin

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Bicyclomycin, discovered in 1972, has a structure that is unique among antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. Bicyclomycin is also effective against the Gram-positive bacterium Micrococcus luteus.[1] It is the only known selective inhibitor of Rho.


Contents

Mode of Action

Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.[1]

Structure

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NLM PubChem Public Chemical Database

Targets

Bicyclomycin targets the transcription termination factor Rho.[2]

Mechanisms of Resistance

Mutations that affect sensitivity

Genes in E. coli that affect sensitivity to bicyclomycin.[3]

Gene Allele Sensitivity to BCM Reference

recA

deletion

increased senstivity

PMID:21357484[3]

recO

deletion

increased sensitivity

PMID:21357484[3]

rdgC

deletion

increased sensitivity

PMID:21357484[3]

trxA

deletion

increased sensitivity

PMID:21357484[3]

trxB

deletion

increased sensitivity

PMID:21357484[3]

minC

deletion

increased sensitivity

PMID:21357484[3]

envC

deletion

increased sensitivity

PMID:21357484[3]

csgG

deletion

increased sensitivity

PMID:21357484[3]

pgpB

deletion

increased sensitivity

PMID:21357484[3]

yciB

deletion

increased sensitivity

PMID:21357484[3]

ydcS

deletion

increased sensitivity

PMID:21357484[3]

ydcX

deletion

increased sensitivity

PMID:21357484[3]

degP

deletion

increased sensitivity

PMID:21357484[3]

dnaK

deletion

increased sensitivity

PMID:21357484[3]

hscA

deletion

increased sensitivity

PMID:21357484[3]

lon

deletion

increased sensitivity

PMID:21357484[3]

rimK

deletion

increased sensitivity

PMID:21357484[3]

rplA

deletion

increased sensitivity

PMID:21357484[3]

rpsF

deletion

increased sensitivity

PMID:21357484[3]

rlmE

deletion

increased sensitivity

PMID:21357484[3]

dapF

deletion

increased sensitivity

PMID:21357484[3]

fabF

deletion

increased sensitivity

PMID:21357484[3]

gpmM

deletion

increased sensitivity

PMID:21357484[3]

iscS

deletion

increased sensitivity

PMID:21357484[3]

ycjU

deletion

increased sensitivity

PMID:21357484[3]

hns

deletion

increased sensitivity

PMID:21357484[3]

yciT

deletion

increased sensitivity

PMID:21357484[3]

rzpQ

deletion

increased sensitivity

PMID:21357484[3]

ydfA

deletion

increased sensitivity

PMID:21357484[3]

ymfT

deletion

increased sensitivity

PMID:21357484[3]

ybaB

deletion

increased sensitivity

PMID:21357484[3]

yciM

deletion

increased sensitivity

PMID:21357484[3]

ydhT

deletion

increased sensitivity

PMID:21357484[3]

yebV

deletion

increased sensitivity

PMID:21357484[3]



References

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  1. 1.0 1.1 Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed EcoliWiki page
  2. Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed EcoliWiki page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 Tran, L et al. (2011) Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J. Bacteriol. 193 2229-35 PubMed EcoliWiki page