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ClpXP

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Description (originally from EcoCyc[1]) ClpXP

Comments (originally from EcoCyc[1]) ClpXP is a serine protease complex responsible for the ATP-dependent degradation of a wide range of proteins [2][3][4][5][6][7][8][9][10][3][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34].


References

  1. ↑ 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ Gottesman S et al. (1993) ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities. J Biol Chem 268: 22618-26 PubMed EcoliWiki page
  3. ↑ 3.0 3.1 Wojtkowiak D et al. (1993) Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli. J Biol Chem 268: 22609-17 PubMed EcoliWiki page
  4. ↑ Welty DJ et al. (1997) Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms. J Mol Biol 272: 31-41 PubMed EcoliWiki page
  5. ↑ Jones JM et al. (1998) Versatile action of Escherichia coli ClpXP as protease or molecular chaperone for bacteriophage Mu transposition. J Biol Chem 273: 459-65 PubMed EcoliWiki page
  6. ↑ Mhammedi-Alaoui A et al. (1994) A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein. Mol Microbiol 11: 1109-16 PubMed EcoliWiki page
  7. ↑ Bohn C et al. (2002) Screening for stabilization of proteins with a trans-translation signature in Escherichia coli selects for inactivation of the ClpXP protease. Mol Genet Genomics 266: 827-31 PubMed EcoliWiki page
  8. ↑ Gottesman S et al. (1998) The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system. Genes Dev 12: 1338-47 PubMed EcoliWiki page
  9. ↑ Kenniston JA et al. (2004) Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation. J Struct Biol 146: 130-40 PubMed EcoliWiki page
  10. ↑ Zylicz M et al. (1998) Formation of the preprimosome protects lambda O from RNA transcription-dependent proteolysis by ClpP/ClpX. Proc Natl Acad Sci U S A 95: 15259-63 PubMed EcoliWiki page
  11. ↑ Czyz A et al. (2001) Rapid degradation of bacteriophage lambda O protein by ClpP/ClpX protease influences the lysis-versus-lysogenization decision of the phage under certain growth conditions of the host cells. Arch Virol 146: 1487-98 PubMed EcoliWiki page
  12. ↑ Stephani K et al. (2003) Dynamic control of Dps protein levels by ClpXP and ClpAP proteases in Escherichia coli. Mol Microbiol 49: 1605-14 PubMed EcoliWiki page
  13. ↑ Schweder T et al. (1996) Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease. J Bacteriol 178: 470-6 PubMed EcoliWiki page
  14. ↑ O'Neill M et al. (2001) Target recognition by EcoKI: the recognition domain is robust and restriction-deficiency commonly results from the proteolytic control of enzyme activity. J Mol Biol 307: 951-63 PubMed EcoliWiki page
  15. ↑ Frank EG et al. (1996) Regulation of SOS mutagenesis by proteolysis. Proc Natl Acad Sci U S A 93: 10291-6 PubMed EcoliWiki page
  16. ↑ Lehnherr H & Yarmolinsky MB (1995) Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Proc Natl Acad Sci U S A 92: 3274-7 PubMed EcoliWiki page
  17. ↑ Flynn JM et al. (2003) Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell 11: 671-83 PubMed EcoliWiki page
  18. ↑ Levchenko I et al. (2000) A specificity-enhancing factor for the ClpXP degradation machine. Science 289: 2354-6 PubMed EcoliWiki page
  19. ↑ Wah DA et al. (2003) Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease. Mol Cell 12: 355-63 PubMed EcoliWiki page
  20. ↑ Bolon DN et al. (2004) Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell 16: 343-50 PubMed EcoliWiki page
  21. ↑ Hersch GL et al. (2004) SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags. Proc Natl Acad Sci U S A 101: 12136-41 PubMed EcoliWiki page
  22. ↑ Flynn JM et al. (2004) Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation. Genes Dev 18: 2292-301 PubMed EcoliWiki page
  23. ↑ Muffler A et al. (1996) The response regulator RssB controls stability of the sigma(S) subunit of RNA polymerase in Escherichia coli. EMBO J 15: 1333-9 PubMed EcoliWiki page
  24. ↑ Zhou Y et al. (2001) The RssB response regulator directly targets sigma(S) for degradation by ClpXP. Genes Dev 15: 627-37 PubMed EcoliWiki page
  25. ↑ Studemann A et al. (2003) Sequential recognition of two distinct sites in sigma(S) by the proteolytic targeting factor RssB and ClpX. EMBO J 22: 4111-20 PubMed EcoliWiki page
  26. ↑ Bolon DN et al. (2004) Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study. Mol Cell 13: 443-9 PubMed EcoliWiki page
  27. ↑ Neher SB et al. (2003) Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease. Proc Natl Acad Sci U S A 100: 13219-24 PubMed EcoliWiki page
  28. ↑ Grimaud R et al. (1998) Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP. J Biol Chem 273: 12476-81 PubMed EcoliWiki page
  29. ↑ Ortega J et al. (2000) Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP. Mol Cell 6: 1515-21 PubMed EcoliWiki page
  30. ↑ Thibault G et al. (2006) Large nucleotide-dependent movement of the N-terminal domain of the ClpX chaperone. EMBO J 25: 3367-76 PubMed EcoliWiki page
  31. ↑ Kim YI et al. (2000) Dynamics of substrate denaturation and translocation by the ClpXP degradation machine. Mol Cell 5: 639-48 PubMed EcoliWiki page
  32. ↑ Wegrzyn A et al. (2000) ClpP/ClpX-mediated degradation of the bacteriophage lambda O protein and regulation of lambda phage and lambda plasmid replication. Arch Microbiol 174: 89-96 PubMed EcoliWiki page
  33. ↑ Makovets S et al. (1998) ClpX and ClpP are essential for the efficient acquisition of genes specifying type IA and IB restriction systems. Mol Microbiol 28: 25-35 PubMed EcoliWiki page
  34. ↑ Szalewska A et al. (1994) Neither absence nor excess of lambda O initiator-digesting ClpXP protease affects lambda plasmid or phage replication in Escherichia coli. Mol Microbiol 13: 469-74 PubMed EcoliWiki page

Pages in category "Complex:ClpXP"

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