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degradosome

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Description (originally from EcoCyc[1]) degradosome

Comments (originally from EcoCyc[1]) The degradosome is a large, multiprotein complex involved in RNA degradation. It consists of the RNA degradation enzymes RNase E and PNPase, as well as the ATP-dependent RNA helicase RhlB and the metabolic enzyme enolase [2][3][4][5][6][7][8][9][10][11][12][13][10][14][15][16][16][17][18][19][20][21][22].

Proteomic analysis has been used to examine components of the degradosome[23]

References

  1. ↑ 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ Py B et al. (1994) A protein complex mediating mRNA degradation in Escherichia coli. Mol Microbiol 14: 717-29 PubMed EcoliWiki page
  3. ↑ Carpousis AJ et al. (1994) Copurification of E. coli RNAase E and PNPase: evidence for a specific association between two enzymes important in RNA processing and degradation. Cell 76: 889-900 PubMed EcoliWiki page
  4. ↑ Py B et al. (1996) A DEAD-box RNA helicase in the Escherichia coli RNA degradosome. Nature 381: 169-72 PubMed EcoliWiki page
  5. ↑ Blum E et al. (1997) Polyphosphate kinase is a component of the Escherichia coli RNA degradosome. Mol Microbiol 26: 387-98 PubMed EcoliWiki page
  6. ↑ Miczak A et al. (1996) Proteins associated with RNase E in a multicomponent ribonucleolytic complex. Proc Natl Acad Sci U S A 93: 3865-9 PubMed EcoliWiki page
  7. ↑ Coburn GA et al. (1999) Reconstitution of a minimal RNA degradosome demonstrates functional coordination between a 3' exonuclease and a DEAD-box RNA helicase. Genes Dev 13: 2594-603 PubMed EcoliWiki page
  8. ↑ Liou GG et al. (2001) RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E. Proc Natl Acad Sci U S A 98: 63-8 PubMed EcoliWiki page
  9. ↑ Kido M et al. (1996) RNase E polypeptides lacking a carboxyl-terminal half suppress a mukB mutation in Escherichia coli. J Bacteriol 178: 3917-25 PubMed EcoliWiki page
  10. ↑ 10.0 10.1 Vanzo NF et al. (1998) Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome. Genes Dev 12: 2770-81 PubMed EcoliWiki page
  11. ↑ Morita T et al. (2004) Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli. Mol Microbiol 54: 1063-75 PubMed EcoliWiki page
  12. ↑ Callaghan AJ et al. (2004) Studies of the RNA degradosome-organizing domain of the Escherichia coli ribonuclease RNase E. J Mol Biol 340: 965-79 PubMed EcoliWiki page
  13. ↑ Leroy A et al. (2002) Function in Escherichia coli of the non-catalytic part of RNase E: role in the degradation of ribosome-free mRNA. Mol Microbiol 45: 1231-43 PubMed EcoliWiki page
  14. ↑ Coburn GA & Mackie GA (1998) Reconstitution of the degradation of the mRNA for ribosomal protein S20 with purified enzymes. J Mol Biol 279: 1061-74 PubMed EcoliWiki page
  15. ↑ Khemici V & Carpousis AJ (2004) The RNA degradosome and poly(A) polymerase of Escherichia coli are required in vivo for the degradation of small mRNA decay intermediates containing REP-stabilizers. Mol Microbiol 51: 777-90 PubMed EcoliWiki page
  16. ↑ 16.0 16.1 Blum E et al. (1999) Polyadenylation promotes degradation of 3'-structured RNA by the Escherichia coli mRNA degradosome in vitro. J Biol Chem 274: 4009-16 PubMed EcoliWiki page
  17. ↑ Bessarab DA et al. (1998) RNA components of Escherichia coli degradosome: evidence for rRNA decay. Proc Natl Acad Sci U S A 95: 3157-61 PubMed EcoliWiki page
  18. ↑ Lin-Chao S et al. (1999) RNase E is required for the maturation of ssrA RNA and normal ssrA RNA peptide-tagging activity. Proc Natl Acad Sci U S A 96: 12406-11 PubMed EcoliWiki page
  19. ↑ Khemici V et al. (2004) The RNase E of Escherichia coli has at least two binding sites for DEAD-box RNA helicases: functional replacement of RhlB by RhlE. Mol Microbiol 54: 1422-30 PubMed EcoliWiki page
  20. ↑ Prud'homme-Genereux A et al. (2004) Physical and functional interactions among RNase E, polynucleotide phosphorylase and the cold-shock protein, CsdA: evidence for a 'cold shock degradosome'. Mol Microbiol 54: 1409-21 PubMed EcoliWiki page
  21. ↑ Feng Y et al. (2001) Escherichia coli poly(A)-binding proteins that interact with components of degradosomes or impede RNA decay mediated by polynucleotide phosphorylase and RNase E. J Biol Chem 276: 31651-6 PubMed EcoliWiki page
  22. ↑ Bernstein JA et al. (2004) Global analysis of Escherichia coli RNA degradosome function using DNA microarrays. Proc Natl Acad Sci U S A 101: 2758-63 PubMed EcoliWiki page
  23. ↑ Regonesi ME et al. (2006) Analysis of the Escherichia coli RNA degradosome composition by a proteomic approach. Biochimie 88: 151-61 PubMed EcoliWiki page

Articles about components of this complex.

There are 5 pages in this category.

e

p

r

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