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galETKM
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Description (originally from EcoCyc[1][2]) galETKM
Regulation of galETKM has been characterized as an incoherent feed-forward loop[3].
Repression by GalR and GalS
Gal regulon genes, including those in the galETKM operon are regulated by galR, the Gal repressor, and galS, the Gal isorepressor[4][5]. Repression at the galETKM promoter involves formation of a repressosome containing GalR dimers bound to two operator sites flanking the promoter region[6].
Activation by CAP-cAMP
Other
(originally from EcoCyc[1][2]) Rob is a transcriptional regulator related with the increase in resistance to antibiotics and is expressed constitutively. Bennik et al have shown that this regulator represses the transcription of galT gene and that it forms multiple complexes in the promoter region, suggesting the existence of multiple Rob binding sites |CITS [ 10850996 ]|.
References
- ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Mangan S et al. (2006) The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli. J Mol Biol 356: 1073-81 PubMed EcoliWiki page
- ↑ Weickert MJ & Adhya S (1993) The galactose regulon of Escherichia coli. Mol Microbiol 10: 245-51 PubMed EcoliWiki page
- ↑ Semsey S et al. (2007) Signal integration in the galactose network of Escherichia coli. Mol Microbiol 65: 465-76 PubMed EcoliWiki page
- ↑ Semsey S et al. (2006) Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA. J Mol Biol 358: 355-63 PubMed EcoliWiki page
Articles about members of this transcription unit
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