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MDS12

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Alternate Names

Sources

Chromosomal Genotype

This is a reduced genome strain derived from E. coli K-12 strain MG1655.[1] The MG1655 genome was reduced by 8.1%. The 12 deletions that were constructed removed most of the cryptic prophages, phage remnants, and IS elements from MG1655. Also deleted were a some genes of unknown function. In total, 409 ORF's and 2 stable RNA genes were deleted.

Plasmids

Phage

Phenotypes

Construction

Notes

Additional reduced genome strains with more of the genome deleted from MG1655 were constructed and characterized by Pósfai et al. (2006). [2]

References

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  1. Kolisnychenko, V et al. (2002) Engineering a reduced Escherichia coli genome. Genome Res. 12 640-7 PubMed EcoliWiki page
  2. Pósfai, G et al. (2006) Emergent properties of reduced-genome Escherichia coli. Science 312 1044-6 PubMed EcoliWiki page