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Kumar, R and Shimizu, K (2010) Metabolic regulation of Escherichia coli and its gdhA, glnL, gltB, D mutants under different carbon and nitrogen limitations in the continuous culture. Microb. Cell Fact. 9:8


It is quite important to understand how the central metabolism is regulated under nitrogen (N)- limitation as well as carbon (C)- limitation. In particular, the effect of C/N ratio on the metabolism is of practical interest for the heterologous protein production, PHB production, etc. Although the carbon and nitrogen metabolisms are interconnected and the overall mechanism is complicated, it is strongly desirable to clarify the effects of culture environment on the metabolism from the practical application point of view.


PubMed PMC2827463 Online version:10.1186/1475-2859-9-8


Carbon/metabolism; Culture Media/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Glutamate Dehydrogenase/genetics; Glutamate Dehydrogenase/metabolism; Glutamate Synthase/genetics; Glutamate Synthase/metabolism; Mutation; Nitrogen/metabolism


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