Han, X, Dorsey-Oresto, A, Malik, M, Wang, JY, Drlica, K, Zhao, X and Lu, T (2010) Escherichia coli genes that reduce the lethal effects of stress. BMC Microbiol. 10:35
The continuing emergence of antimicrobial resistance requires the development of new compounds and/or enhancers of existing compounds. Genes that protect against the lethal effects of antibiotic stress are potential targets of enhancers. To distinguish such genes from those involved in drug uptake and efflux, a new susceptibility screen is required.
Anti-Bacterial Agents/pharmacology; DNA, Bacterial/genetics; Drug Resistance, Bacterial/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Gene Expression Regulation, Bacterial; Gene Library; Genes, Bacterial; Genetic Complementation Test; Hot Temperature; Hydrogen Peroxide/pharmacology; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Mutagenesis, Insertional; Nalidixic Acid/pharmacology; Phenotype; Sequence Analysis, DNA; Stress, Physiological; Transduction, Genetic; Ultraviolet Rays
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