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Cox, J and Putonti, C (2010) Mechanisms responsible for a PhiX174 mutant's ability to infect Escherichia coli by phosphorylation. J. Virol. 84:4860-3


The ability for a virus to expand its host range is dependent upon a successful mode of viral entry. As such, the host range of the well-studied PhiX174 bacteriophage is dictated by the presence of a particular lipopolysaccharide (LPS) on the bacterial surface. The mutant PhiX174 strain JACS-K, unlike its ancestor, is capable of infecting both its native host Escherichia coli C and E. coli K-12, which does not have the necessary LPS. The conversion of an alanine to a very reactive threonine on its virion surface was found to be responsible for the strain's expanded host range.


PubMed PMC2863744 Online version:10.1128/JVI.00047-10


Amino Acid Substitution/genetics; Bacteriophage phi X 174/genetics; Bacteriophage phi X 174/growth & development; Bacteriophage phi X 174/physiology; Escherichia coli/virology; Phosphorylation; Viral Proteins/genetics; Viral Proteins/metabolism; Virus Attachment


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