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Gene Name

accC (synonyms: ECK3243, b3256, JW3224)[1]

Product(s)

AccC product[1]: acetyl-CoA carboxylase, biotin carboxylase subunit product, B3256 product

Description

AccC[2][3]

Component of biotin carboxylase[2],acetyl CoA carboxylase[2]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): accBC[2]

Regulation/Activity
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Notes

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Gene

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Nomenclature

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Standard name

accC

Mnemonic
Synonyms

ECK3243, b3256, JW3224[1]

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Notes

Location(s) and DNA Sequence

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StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

73.37 minutes 

MG1655: 3403939..3405288
gbrowse_img.php?coord=3402939..3406288&genome=ecoli&name=MG1655&trackset=0&width=300&.png

W3110

 

W3110: 3405772..3407121
gbrowse_img.php?coord=3404772..3408121&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

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Notes

Sequence Features

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Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments
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Notes

Genetic Resources

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ResourceResource TypeSourceNotes/Reference

JW3224

Plasmid clone

Shigen

PMID:16769691[4]

Status:Clone OK

Primer 1:GCCCTGGATAAAATTGTTATTGC

Primer 2:CCTTTTTCCTGAAGACCGAGTTT

zhc-6::Tn10

Linked marker

CAG12153 = CGSC7442[5]

est. P1 cotransduction: 18% [6]

Synonyms:zha-6::Tn10

acrF3083::Tn10

Linked marker

CAG12075 = CGSC7447[5]

est. P1 cotransduction: 69% [6]

Synonyms:zhd-3083::Tn10, zhe-3083::Tn10

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Notes

Accessions in Other Databases

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10276

EchoBASE (EcoliWiki Page)

EchoBASE:EB0272

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b3256

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C4012

EcoGene (EcoliWiki Page)

EcoGene:EG10276

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:ACCC

CGSC (EcoliWiki Page)

CGSC:29834

ASAP (EcoliWikiPage)

ASAP:ABE-0010677


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Notes

Links

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NameURLComments
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Categories

Product(s)

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Nomenclature

Standard name

AccC

Synonyms

acetyl-CoA carboxylase, biotin carboxylase subunit[1], B3256[2][1], AccC[2][1]

Product description

AccC[2][3];

Component of ; biotin carboxylase[2][3]; acetyl CoA carboxylase[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0006633

fatty acid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc 12.5 [7]

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0003824

catalytic activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011761
InterPro:IPR013816
InterPro:IPR013817

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0003989

acetyl-CoA carboxylase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.4.1.2

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0004075

biotin carboxylase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.3.4.14

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0005524

ATP binding

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR005479
InterPro:IPR011761
InterPro:IPR011764
InterPro:IPR013816
InterPro:IPR013817
SP_KW:KW-0067

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0016874

ligase activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004549
InterPro:IPR005481
InterPro:IPR005482
InterPro:IPR011764
SP_KW:KW-0436

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005481

P

Seeded from EcoCyc 12.5 [7]

complete

GO:0008610

lipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc 12.5 [7]

complete

GO:0009374

biotin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011764

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0006654

phosphatidic acid biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions

Partner TypePartnerNotesReferences

Protein

Subunits of biotin carboxylase

could be indirect

Protein

Subunits of acetyl CoA carboxylase

could be indirect


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Notes

Localization

CompartmentDescriptionEvidenceNotes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MLDKIVIANR GEIALRILRA CKELGIKTVA VHSSADRDLK HVLLADETVC IGPAPSVKSY
LNIPAIISAA EITGAVAIHP GYGFLSENAN FAEQVERSGF IFIGPKAETI RLMGDKVSAI
AAMKKAGVPC VPGSDGPLGD DMDKNRAIAK RIGYPVIIKA SGGGGGRGMR VVRGDAELAQ
SISMTRAEAK AAFSNDMVYM EKYLENPRHV EIQVLADGQG NAIYLAERDC SMQRRHQKVV
EEAPAPGITP ELRRYIGERC AKACVDIGYR GAGTFEFLFE NGEFYFIEMN TRIQVEHPVT
EMITGVDLIK EQLRIAAGQP LSIKQEEVHV RGHAVECRIN AEDPNTFLPS PGKITRFHAP
GGFGVRWESH IYAGYTVPPY YDSMIGKLIC YGENRDVAIA RMKNALQELI IDGIKTNVDL
QIRIMNDENF QHGGTNIHYL EKKLGLQEK
Mol. Wt

49.32 kDa (calc) [2]

pI

7.08[2]

Extinction coefficient

27850 - 28850 (calc based on 15 Y, 1 W, and 8 C residues)

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Domains/Motifs/Modification Sites

TypeResiduesDescriptionNotes

Domain

1 - 445

Biotin carboxylation

UniProt:P24182

Domain

120 - 317

ATP-grasp

UniProt:P24182

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Structure

Structures
  • Representative Escherichia coli structure:
    1DV2|A
    4-452 of 449 residues (E-value: 1.4e-241) (Percent Identity: 99.78)
  • Representative homolog:
    2YW2|A (Aquifex aeolicus)
    80-342 of 449 residues (E-value: 1.2e-07) (Percent Identity: 25.64)
  • View all other structures.
Models

View models at:

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Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:BIOTIN-CARBOXYL-MONOMER

UniProt (EcoliWiki Page)

UniProt:P24182

PFAM (EcoliWiki Page)

PFAM:PF00289

RefSeq (EcoliWiki Page)

RefSeq:NP_417722

ModBase (EcoliWiki Page)

ModBase:P24182

PDB (EcoliWiki Page)

PDB:1BNC


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Notes

Links

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NameURLComments
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Categories

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Transcription and Transcriptional Regulation

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Transcription unit(s)

accBC

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Figure courtesy of RegulonDB
Figure courtesy of RegulonDB

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=3403919..3403959&genome=ecoli&name=MG1655&trackset=Genes_unlabeled+DNA_unlabeled&width=400&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression

Allele NameMutationPhenotypeReference
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Expression Studies

TypeReferenceNotes

microarray

GenExpDB:b3256 (EcoliWiki Page)

Summary of data for accC from multiple microarray studies

microarray

GEO Profiles:b3256 (EcoliWiki Page)

NCBI GEO profiles for accC

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Expression Resources

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to accC Expression

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10276

EchoBASE (EcoliWiki Page)

EchoBASE:EB0272

EcoliGenExpDB (EcoliWiki Page)

GenExpDB:b3256

EcoGene (EcoliWiki Page)

EcoGene:EG10276

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Notes

Links

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NameURLComments
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Categories

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Evolution

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Homologs in Other Organisms

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OrganismHomologs (Statistics)Comments

Anopheles gambiae

  • ENSANGP00000023222 (score: 1.000; bootstrap: 86%)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000032346 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT5G35360 (score: 1.000; bootstrap: 97%)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000008604 (score: 1.000; bootstrap: 74%)

From Inparanoid:20070104

Caenorhabditis briggsae

  • WBGene00036608 (score: 1.000; bootstrap: 100%)
  • WBGene00026327 (score: 0.076)

From Inparanoid:20070104

Caenorhabditis elegans

  • WBGene00017864 (score: 1.000; bootstrap: 93%)
  • WBGene00009319 (score: 0.065)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000017309 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000016531 (score: 1.000; bootstrap: 91%)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-040718-246 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-040718-274 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0230063 (score: 1.000; bootstrap: 99%)
  • DDB0230065 (score: 0.060)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0027580 (score: 1.000; bootstrap: 62%)

From Inparanoid:20070104

Drosophila pseudoobscura

  • GA13539-PA (score: 1.000; bootstrap: 62%)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000032512 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000308554 (score: 1.000; bootstrap: 99%)
  • ENSP00000265594 (score: 0.054)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000013840 (score: 1.000; bootstrap: 99%)
  • ENSMMUP00000005991 (score: 0.076)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000009482 (score: 1.000; bootstrap: 91%)

From Inparanoid:20070104

Mus musculus

  • MGI:1919289 (score: 1.000; bootstrap: 99%)
  • MGI:97499 (score: 0.052)

From Inparanoid:20070104

Oryza gramene

  • Q41511 (score: 1.000; bootstrap: 100%)
  • Q41525 (score: 1.000; bootstrap: 100%)
  • Q8S6N5 (score: 0.884)
  • Q7XYR4 (score: 0.692)
  • Q7XYR3 (score: 0.691)
  • Q84TQ5 (score: 0.690)
  • Q947M6 (score: 0.689)
  • Q41743 (score: 0.689)
  • Q84TQ6 (score: 0.686)
  • O48959 (score: 0.685)
  • Q8LRK2 (score: 0.676)
  • Q43248 (score: 0.477)
  • Q08367 (score: 0.463)
  • Q94FR6 (score: 0.284)
  • Q94FR7 (score: 0.283)
  • Q94FR5 (score: 0.279)
  • Q94FR8 (score: 0.275)
  • Q94FS0 (score: 0.273)
  • Q94FR9 (score: 0.272)
  • Q94FS1 (score: 0.271)
  • Q9ZPN1 (score: 0.263)
  • Q5CCG4 (score: 0.241)
  • Q66RP8 (score: 0.235)
  • Q9LL90 (score: 0.178)
  • Q9LDT4 (score: 0.178)
  • Q9LL89 (score: 0.177)
  • Q84U78 (score: 0.177)
  • Q84U79 (score: 0.177)
  • Q40010 (score: 0.174)
  • Q7G1H3 (score: 0.145)
  • O48960 (score: 0.145)
  • Q7XYR1 (score: 0.141)
  • Q7XYR2 (score: 0.140)
  • Q506J0 (score: 0.130)
  • Q506J8 (score: 0.130)
  • Q506J3 (score: 0.130)
  • Q506J5 (score: 0.130)
  • Q506J4 (score: 0.130)
  • Q506J1 (score: 0.129)
  • Q08737 (score: 0.128)
  • Q506J2 (score: 0.128)
  • Q7XHK2 (score: 0.062)
  • Q8VWG1 (score: 0.060)
  • Q947K2 (score: 0.056)
  • Q947K1 (score: 0.056)
  • Q947K0 (score: 0.056)
  • Q947J9 (score: 0.056)
  • Q947J8 (score: 0.056)
  • Q93WH4 (score: 0.056)
  • Q93WH3 (score: 0.056)
  • Q93WH2 (score: 0.056)
  • Q93WH1 (score: 0.056)
  • Q947J6 (score: 0.056)
  • Q947J5 (score: 0.055)
  • Q947J4 (score: 0.055)
  • Q947J7 (score: 0.055)
  • Q850M1 (score: 0.054)
  • Q84K29 (score: 0.054)
  • Q947I9 (score: 0.054)
  • Q947J0 (score: 0.053)
  • Q947I8 (score: 0.053)
  • Q947J3 (score: 0.053)
  • Q947J2 (score: 0.052)
  • Q947J1 (score: 0.052)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000026948 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000018942 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YGL062W (score: 1.000; bootstrap: 80%)
  • YBR218C (score: 0.933)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPBC17G91c (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000173073 (score: 1.000; bootstrap: 99%)
  • NEWSINFRUP00000144429 (score: 0.059)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00013003001 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000031615 (score: 1.000; bootstrap: 82%)

From Inparanoid:20070104

Shigella flexneri

ACCC

From SHIGELLACYC

E. coli O157

ACCC

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00289

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Notes

Links

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NameURLComments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Kitagawa M et al. (2005) Complete set of ORF clones of Escherichia coli ASKA library (A Complete Set of E. coli K-12 ORF Archive): Unique Resources for Biological Research. DNA Res 12: 291-9 PubMed EcoliWiki page
  5. ↑ 5.0 5.1 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

Categories

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