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accD:On One Page

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Gene Name	accD (synonyms: ECK2310, b2316, JW2313, dedB)^[1]
Product(s)	AccD product^[1]: acetyl-CoA carboxylase, beta (carboxyltranferase) subunit product, B2316 product, DedB product
Description	AccD^[2]^[3] Component of carboxyl transferase subunit β^[2],acetyl-CoA carboxyltransferase^[2],acetyl CoA carboxylase^[2]
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): accD^[2]
Regulation/Activity
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Gene

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Nomenclature

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Standard name	accD
Mnemonic
Synonyms	ECK2310, b2316, JW2313, dedB^[1]
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Notes

Location(s) and DNA Sequence

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Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	52.4 minutes, 52.4 minutes	MG1655: 2431948..2431034	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
W3110		W3110: 2439372..2438458	GBrowse(W3110)	FASTA Dump
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Strain

Map location

Genome coordinates

Genome browsers

Sequence links

MG1655

52.4 minutes, 52.4 minutes

MG1655: 2431948..2431034
gbrowse_img.php?coord=2430034..2432948&genome=ecoli&name=MG1655&trackset=0&width=300&.png

EcoCyc

GBrowse(MG1655)

W3110

W3110: 2439372..2438458
gbrowse_img.php?coord=2437458..2440372&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

GBrowse(W3110)

FASTA Dump

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Notes

Sequence Features

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Feature type	Location	Description
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Notes

Alleles and Phenotypes

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Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
accD6(ts)				temperature sensitive	PMID:4564200^[4] PMID:4597230^[5] PMID:1355086^[6]	CGSC:64607
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Notes

Genetic Resources

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Resource	Resource Type	Source	Notes/Reference
JW2313	Plasmid clone	Shigen	PMID:16769691^[7] Status:Clone OK Primer 1:GCCAGCTGGATTGAACGAATTAA Primer 2:CCGGCCTCAGGTTCCTGATCCGG
zfb-223::Tn10	Linked marker	CAG18484 = CGSC7406^[8]	est. P1 cotransduction: 17% ^[9] Synonyms:zej-223::Tn10
zfd-1::Tn10	Linked marker	CAG18467 = CGSC7408^[8]	est. P1 cotransduction: 4% ^[9] Synonyms:zfb-1::Tn10
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:EG10217
EchoBASE (EcoliWiki Page)	EchoBASE:EB0213
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2316
ECOL199310CYC (EcoliWiki Page)	ECOL199310CYC:C2861
EcoGene (EcoliWiki Page)	EcoGene:EG10217
ECOO157CYC (EcoliWiki Page)	ECOO157CYC:ACCD
CGSC (EcoliWiki Page)	CGSC:28570
ASAP (EcoliWikiPage)	ASAP:ABE-0007648
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Links

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Name	URL	Comments
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Product(s)

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Nomenclature

Standard name	AccD
Synonyms	acetyl-CoA carboxylase, beta (carboxyltranferase) subunit^[1], B2316^[2]^[1], DedB^[2]^[1], AccD^[2]^[1]
Product description	AccD^[2]^[3]; Component of ; carboxyl transferase subunit β^[2]^[3]; acetyl-CoA carboxyltransferase^[2]^[3]; acetyl CoA carboxylase^[2]^[3]
EC number (for enzymes)	6.4.1.2^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006633	fatty acid biosynthetic process	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000438 SP_KW:KW-0275	P	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0003989	acetyl-CoA carboxylase activity	GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR000438 EC:6.4.1.2	F	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0008270	zinc ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0862	F	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0008610	lipid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0444	P	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0009317	acetyl-CoA carboxylase complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000438	C	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0016874	ligase activity	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000022 InterPro:IPR011762 SP_KW:KW-0436	F	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0005515	protein binding	PMID:15690043^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P0ABD5	F	Seeded from EcoCyc 12.5 ^[10]	complete
	GO:0005737	cytoplasm				C	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0006654	phosphatidic acid biosynthetic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
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Interactions

Partner Type	Partner	Notes
Protein	Subunits of carboxyl transferase subunit β	could be indirect
Protein	Subunits of acetyl-CoA carboxyltransferase	could be indirect
Protein	Subunits of acetyl CoA carboxylase	could be indirect
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Notes

Localization

Compartment	Description	Evidence	Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MSWIERIKSN ITPTRKASIP EGVWTKCDSC GQVLYRAELE RNLEVCPKCD HHMRMTARNR LHSLLDEGSL VELGSELEPK DVLKFRDSKK YKDRLASAQK ETGEKDALVV MKGTLYGMPV VAAAFEFAFM GGSMGSVVGA RFVRAVEQAL EDNCPLICFS ASGGARMQEA LMSLMQMAKT SAALAKMQER GLPYISVLTD PTMGGVSASF AMLGDLNIAE PKALIGFAGP RVIEQTVREK LPPGFQRSEF LIEKGAIDMI VRRPEMRLKL ASILAKLMNL PAPNPEAPRE GVVVPPVPDQ EPEA
Mol. Wt	33.32 kDa (calc) ^[2]
pI	8.77^[2]
Extinction coefficient	16960 - 17710 (calc based on 4 Y, 2 W, and 6 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structures	Representative Escherichia coli structure: 2F9Y\|B 1-304 of 304 residues (E-value: 4.4e-160) (Percent Identity: 100.00) Representative homolog: 1X0U\|A (Sulfolobus tokodaii) 39-261 of 304 residues (E-value: 1.1e-10) (Percent Identity: 27.50) View all other structures.
Models	View models at: EcoliPredict ModBase PSI-PRED Protein Quaternary Structure (PQS) Genomes TO Protein (GTOP)
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Structures

Representative Escherichia coli structure:
2F9Y|B
1-304 of 304 residues (E-value: 4.4e-160) (Percent Identity: 100.00)
Representative homolog:
1X0U|A (Sulfolobus tokodaii)
39-261 of 304 residues (E-value: 1.1e-10) (Percent Identity: 27.50)
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Models

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:CARBOXYL-TRANSFERASE-BETA-MONOMER
UniProt (EcoliWiki Page)	UniProt:P0A9Q5
RefSeq (EcoliWiki Page)	RefSeq:NP_416819
ModBase (EcoliWiki Page)	ModBase:P0A9Q5
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Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Transcription and Transcriptional Regulation

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Transcription unit(s)
accD
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=2431928..2431968&genome=ecoli&name=MG1655&trackset=Genes_unlabeled+DNA_unlabeled+flip&width=400&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression

Allele Name	Mutation	Phenotype	Reference
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Expression Studies

Type	Reference	Notes
microarray	GenExpDB:b2316 (EcoliWiki Page)	Summary of data for accD from multiple microarray studies
microarray	GEO Profiles:b2316 (EcoliWiki Page)	NCBI GEO profiles for accD
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Expression Resources

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to accD Expression

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:EG10217
EchoBASE (EcoliWiki Page)	EchoBASE:EB0213
EcoliGenExpDB (EcoliWiki Page)	GenExpDB:b2316
EcoGene (EcoliWiki Page)	EcoGene:EG10217
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Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000000860 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000020252 (score: 1.000; bootstrap: 100%) ENSBTAP00000006126 (score: 0.093)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00034728 (score: 1.000; bootstrap: 100%) WBGene00029023 (score: 0.180)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00018701 (score: 1.000; bootstrap: 100%) WBGene00008514 (score: 0.174)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000010760 (score: 1.000; bootstrap: 100%) ENSCAFP00000011689 (score: 0.158)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000016122 (score: 1.000; bootstrap: 100%) ENSCINP00000018880 (score: 0.163) ENSCINP00000005637 (score: 0.083)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-040426-2467 (score: 1.000; bootstrap: 100%) ZDB-CDNA-040425-3414 (score: 1.000; bootstrap: 100%) ZDB-CDNA-040425-3440 (score: 0.149) ZDB-GENE-040426-2493 (score: 0.149)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0166993 (score: 1.000; bootstrap: 100%) DDB0168580 (score: 0.172)	From Inparanoid:20070104
Drosophila pseudoobscura	GA17055-PA (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000001845 (score: 1.000; bootstrap: 100%) ENSGALP00000003974 (score: 0.104) ENSGALP00000018342 (score: 0.102)	From Inparanoid:20070104
Homo sapiens	ENSP00000251654 (score: 1.000; bootstrap: 100%) ENSP00000343657 (score: 0.149)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000023102 (score: 1.000; bootstrap: 100%) ENSMODP00000002007 (score: 0.143) ENSMODP00000000863 (score: 0.092)	From Inparanoid:20070104
Mus musculus	MGI:1914154 (score: 1.000; bootstrap: 100%) MGI:1925288 (score: 0.152)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000021657 (score: 1.000; bootstrap: 100%) ENSRNOP00000023900 (score: 0.136)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000137640 (score: 1.000; bootstrap: 100%) NEWSINFRUP00000176970 (score: 0.098) NEWSINFRUP00000128319 (score: 0.085)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00012729001 (score: 1.000; bootstrap: 100%) GSTENP00029632001 (score: 0.101) GSTENP00023172001 (score: 0.080)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000014779 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	ACCD	From SHIGELLACYC
E. coli O157	ACCD	From ECOO157CYC
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Notes

Families

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Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000000860 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000020252 (score: 1.000; bootstrap: 100%) ENSBTAP00000006126 (score: 0.093)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00034728 (score: 1.000; bootstrap: 100%) WBGene00029023 (score: 0.180)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00018701 (score: 1.000; bootstrap: 100%) WBGene00008514 (score: 0.174)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000010760 (score: 1.000; bootstrap: 100%) ENSCAFP00000011689 (score: 0.158)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000016122 (score: 1.000; bootstrap: 100%) ENSCINP00000018880 (score: 0.163) ENSCINP00000005637 (score: 0.083)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-040426-2467 (score: 1.000; bootstrap: 100%) ZDB-CDNA-040425-3414 (score: 1.000; bootstrap: 100%) ZDB-CDNA-040425-3440 (score: 0.149) ZDB-GENE-040426-2493 (score: 0.149)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0166993 (score: 1.000; bootstrap: 100%) DDB0168580 (score: 0.172)	From Inparanoid:20070104
Drosophila pseudoobscura	GA17055-PA (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000001845 (score: 1.000; bootstrap: 100%) ENSGALP00000003974 (score: 0.104) ENSGALP00000018342 (score: 0.102)	From Inparanoid:20070104
Homo sapiens	ENSP00000251654 (score: 1.000; bootstrap: 100%) ENSP00000343657 (score: 0.149)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000023102 (score: 1.000; bootstrap: 100%) ENSMODP00000002007 (score: 0.143) ENSMODP00000000863 (score: 0.092)	From Inparanoid:20070104
Mus musculus	MGI:1914154 (score: 1.000; bootstrap: 100%) MGI:1925288 (score: 0.152)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000021657 (score: 1.000; bootstrap: 100%) ENSRNOP00000023900 (score: 0.136)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000137640 (score: 1.000; bootstrap: 100%) NEWSINFRUP00000176970 (score: 0.098) NEWSINFRUP00000128319 (score: 0.085)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00012729001 (score: 1.000; bootstrap: 100%) GSTENP00029632001 (score: 0.101) GSTENP00023172001 (score: 0.080)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000014779 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	ACCD	From SHIGELLACYC
E. coli O157	ACCD	From ECOO157CYC
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Links

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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Harder ME et al. (1972) Temperature-sensitive mutants of Escherichia coli requiring saturated and unsaturated fatty acids for growth: isolation and properties. Proc Natl Acad Sci U S A 69: 3105-9 PubMed EcoliWiki page
↑ Silbert DF et al. (1974) Proceedings: Genetic engineering of membrane lipid. Fed Proc 33: 1725-32 PubMed EcoliWiki page
↑ Li SJ et al. (1992) The dedB (usg) open reading frame of Escherichia coli encodes a subunit of acetyl-coenzyme A carboxylase. J Bacteriol 174: 5755-7 PubMed EcoliWiki page
↑ Kitagawa M et al. (2005) Complete set of ORF clones of Escherichia coli ASKA library (A Complete Set of E. coli K-12 ORF Archive): Unique Resources for Biological Research. DNA Res 12: 291-9 PubMed EcoliWiki page
↑ ^8.0 ^8.1 CGSC: The Coli Genetics Stock Center
↑ ^9.0 ^9.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page

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accD:On One Page

From EcoliWiki

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Categories

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Categories

Expression

Overview

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to accD Expression

Notes

Links

Categories

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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