Standard name	AcnB
Synonyms	bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase^[1], B0118^[2]^[1], YacI^[2]^[1], YacJ^[2]^[1], AcnB^[2]^[1]
Product description	ACONITATEDEHYDRB^[2]^[3]
EC number (for enzymes)	4.2.1.3^[1] 4.2.1.99^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003994	aconitate hydratase activity	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR004406 InterPro:IPR015929 InterPro:IPR015930 InterPro:IPR015933 EC:4.2.1.3	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0005506	iron ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0408	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0005515	protein binding	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004406 InterPro:IPR015929 InterPro:IPR015933	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004406 InterPro:IPR015930 SP_KW:KW-0004	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0051536	iron-sulfur cluster binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0411	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006099	tricarboxylic acid cycle	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004406 InterPro:IPR015929 InterPro:IPR015930 InterPro:IPR015933 SP_KW:KW-0816	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0008152	metabolic process	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001030 InterPro:IPR015928 InterPro:IPR015931 InterPro:IPR015932 InterPro:IPR015937	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0005737	cytoplasm				C	Seeded from Riley et al 2006 ^[1].	required fields missing
	GO:0003994	aconitate hydratase activity	PMID:8932712^[5]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0009060	aerobic respiration				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0009061	anaerobic respiration				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0019395	fatty acid oxidation				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0016052	carbohydrate catabolic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0003994	aconitate hydratase activity	PMID:8932712^[5]	IDA: Inferred from Direct Assay		F		complete
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Interactions

Partner Type	Partner	Notes	References
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Notes

Localization

Compartment	Description	Evidence	Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MLEEYRKHVA ERAAEGIAPK PLDANQMAAL VELLKNPPAG EEEFLLDLLT NRVPPGVDEA AYVKAGFLAA IAKGEAKSPL LTPEKAIELL GTMQGGYNIH PLIDALDDAK LAPIAAKALS HTLLMFDNFY DVEEKAKAGN EYAKQVMQSW ADAEWFLNRP ALAEKLTVTV FKVTGETNTD DLSPAPDAWS RPDIPLHALA MLKNAREGIE PDQPGVVGPI KQIEALQQKG FPLAYVGDVV GTGSSRKSAT NSVLWFMGDD IPHVPNKRGG GLCLGGKIAP IFFNTMEDAG ALPIEVDVSN LNMGDVIDVY PYKGEVRNHE TGELLATFEL KTDVLIDEVR AGGRIPLIIG RGLTTKAREA LGLPHSDVFR QAKDVAESDR GFSLAQKMVG RACGVKGIRP GAYCEPKMTS VGSQDTTGPM TRDELKDLAC LGFSADLVMQ SFCHTAAYPK PVDVNTHHTL PDFIMNRGGV SLRPGDGVIH SWLNRMLLPD TVGTGGDSHT RFPIGISFPA GSGLVAFAAA TGVMPLDMPE SVLVRFKGKM QPGITLRDLV HAIPLYAIKQ GLLTVEKKGK KNIFSGRILE IEGLPDLKVE QAFELTDASA ERSAAGCTIK LNKEPIIEYL NSNIVLLKWM IAEGYGDRRT LERRIQGMEK WLANPELLEA DADAEYAAVI DIDLADIKEP ILCAPNDPDD ARPLSAVQGE KIDEVFIGSC MTNIGHFRAA GKLLDAHKGQ LPTRLWVAPP TRMDAAQLTE EGYYSVFGKS GARIEIPGCS LCMGNQARVA DGATVVSTST RNFPNRLGTG ANVFLASAEL AAVAALIGKL PTPEEYQTYV AQVDKTAVDT YRYLNFNQLS QYTEKADGVI FQTAV
Mol. Wt	93.5 kDa (calc) ^[2]
pI
Extinction coefficient	75290 - 76540 (calc based on 21 Y, 8 W, and 10 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structures	Representative Escherichia coli structure: 1L5J\|A 1-865 of 865 residues (E-value: 0.) (Percent Identity: 100.00) Representative homolog: 1B0M\|A (Sus scrofa) 298-482 of 865 residues (E-value: 2.5e-08) (Percent Identity: 27.96) View all other structures.
Models	View models at: EcoliPredict ModBase PSI-PRED Protein Quaternary Structure (PQS) Genomes TO Protein (GTOP)
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Structures

Representative Escherichia coli structure:
1L5J|A
1-865 of 865 residues (E-value: 0.) (Percent Identity: 100.00)
Representative homolog:
1B0M|A (Sus scrofa)
298-482 of 865 residues (E-value: 2.5e-08) (Percent Identity: 27.96)
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Models

View models at:

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:ACONITATEDEHYDRB-MONOMER
UniProt (EcoliWiki Page)	UniProt:P36683
PFAM (EcoliWiki Page)	PFAM:PF06434
RefSeq (EcoliWiki Page)	RefSeq:NP_414660
ModBase (EcoliWiki Page)	ModBase:P36683
PDB (EcoliWiki Page)	PDB:1L5J
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^5.0 ^5.1 Bradbury AJ et al. (1996) The second aconitase (AcnB) of Escherichia coli. Microbiology 142 ( Pt 2): 389-400 PubMed EcoliWiki page

acnB:Gene Product(s)

From EcoliWiki

Nomenclature

Notes

Function

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Localization

Notes

Structure and Physical Properties

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Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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