acpP:Gene Product(s) - EcoliWiki
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acpP:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

AcpP

Synonyms

acyl carrier protein (ACP)[1], B1094[2][1]

Product description

lipoyl-ACP[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0042967

acyl-carrier-protein biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0000036

acyl carrier activity

PMID:15459190[4]

IDA: Inferred from Direct Assay

F

complete

GO:0006633

fatty acid biosynthetic process

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008610

lipid biosynthetic process

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0031177

phosphopantetheine binding

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005737

cytoplasm

PMID:15459190[4]

IDA: Inferred from Direct Assay

C

complete

GO:0042493

response to drug

PMID:15459190[4]

IMP: Inferred from Mutant Phenotype

P

N-pentylpantothenamide and N-heptylpantothenamide

complete

GO:0000035

acyl binding

PMID:15459190[4]

IDA: Inferred from Direct Assay

F

complete

GO:0009245

lipid A biosynthetic process

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions

Partner TypePartnerNotesReferences
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Notes

Localization

CompartmentDescriptionEvidenceNotes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc

MSTIEERVKK IIGEQLGVKQ EEVTNNASFV EDLGADSLDT VELVMALEEE FDTEIPDEEA
EKITTVQAAI DYINGHQA
Mol. Wt

8.64 kDa (calc) [2]

pI
Extinction coefficient

1490 (calc based on 1 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

TypeResiduesDescriptionNotes
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Structure

Structures
  • Representative Escherichia coli structure:
    3EJB|A
    20-97 of 78 residues (E-value: 2.0e-36) (Percent Identity: 100.00)
  • Representative homolog:
    1X3O|A (Thermus thermophilus)
    6-75 of 78 residues (E-value: 1.0e-18) (Percent Identity: 62.86)
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Models

View models at:

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Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:LIPOYL-ACP

UniProt (EcoliWiki Page)

UniProt:P02901

PFAM (EcoliWiki Page)

PFAM:PF00550

RefSeq (EcoliWiki Page)

RefSeq:NP_415612

ModBase (EcoliWiki Page)

ModBase:P02901

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:ACP


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Notes

Links

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NameURLComments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 4.2 4.3 Zhang YM et al. (2004) Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J Biol Chem 279: 50969-75 PubMed EcoliWiki page
  5. 5.0 5.1 5.2 5.3 De Lay NR & Cronan JE (2006) Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. J Bacteriol 188: 287-96 PubMed EcoliWiki page


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