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Standard Name


Gene Synonym(s)

ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA[1]

Product Desc.

AcrA Membrane Fusion Protein[2][3];

Component of AcrAB-TolC Multidrug Efflux System[2]; AcrAB-TolC Multidrug Efflux Transport System[3]

AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein[4]

Product Synonyms(s)

multidrug efflux system[1], B0463[2][1], SipB[2][1], Mbl[2][1], Lir[2][1], NbsA[2][1], MtcA[2][1], AcrA[2][1], acridine efflux pump[2][1] , ECK0457, JW0452, lir, Mb, mbl, mtcA, sipB, b0463

Function from GO

Molecular Function

Knock-Out Phenotype

transcription unit(s): acrAB[2]

Quick Links

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acrA was first identified as an acridine sensitive mutation. acrA is a mutational suppressor of topA deletion inviability in low osmolarity medium. AcrA is attached to the inner membrane. acrA is an acrE paralog. AcrA is trimeric. Mar regulon. First 24 aa are a type II signal peptide.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.