acrF:Gene Product(s) - EcoliWiki
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acrF:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

AcrF

Synonyms

multidrug efflux system protein[1], B3266[2][1], EnvD[2][1], AcrF[2][1]

Product description

AcrF[2][3];

Component of ; AcrEF-TolC Multidrug Efflux Transport System[3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0005215

transporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004764

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004764
SP_KW:KW-0813

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0007049

cell cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016021

integral to membrane

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004764
SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0051301

cell division

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0132

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0015292

uniporter activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions

Partner TypePartnerNotesReferences

Protein

Subunits of AcrEF-TolC Multidrug Efflux Transport System

could be indirect


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Notes

Localization

CompartmentDescriptionEvidenceNotes

plasma membrane

C-terminus localized in the cytoplasm with 12 predicted transmembrane domains

Daley et al. (2005) [5]/>

plasma membrane

From EcoCyc[3]

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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MANFFIRRPI FAWVLAIILM MAGALAILQL PVAQYPTIAP PAVSVSANYP GADAQTVQDT
VTQVIEQNMN GIDNLMYMSS TSDSAGSVTI TLTFQSGTDP DIAQVQVQNK LQLATPLLPQ
EVQQQGISVE KSSSSYLMVA GFVSDNPGTT QDDISDYVAS NVKDTLSRLN GVGDVQLFGA
QYAMRIWLDA DLLNKYKLTP VDVINQLKVQ NDQIAAGQLG GTPALPGQQL NASIIAQTRF
KNPEEFGKVT LRVNSDGSVV RLKDVARVEL GGENYNVIAR INGKPAAGLG IKLATGANAL
DTAKAIKAKL AELQPFFPQG MKVLYPYDTT PFVQLSIHEV VKTLFEAIML VFLVMYLFLQ
NMRATLIPTI AVPVVLLGTF AILAAFGYSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
MEDKLPPKEA TEKSMSQIQG ALVGIAMVLS AVFIPMAFFG GSTGAIYRQF SITIVSAMAL
SVLVALILTP ALCATLLKPV SAEHHENKGG FFGWFNTTFD HSVNHYTNSV GKILGSTGRY
LLIYALIVAG MVVLFLRLPS SFLPEEDQGV FLTMIQLPAG ATQERTQKVL DQVTDYYLKN
EKANVESVFT VNGFSFSGQA QNAGMAFVSL KPWEERNGDE NSAEAVIHRA KMELGKIRDG
FVIPFNMPAI VELGTATGFD FELIDQAGLG HDALTQARNQ LLGMAAQHPA SLVSVRPNGL
EDTAQFKLEV DQEKAQALGV SLSDINQTIS TALGGTYVND FIDRGRVKKL YVQADAKFRM
LPEDVDKLYV RSANGEMVPF SAFTTSHWVY GSPRLERYNG LPSMEIQGEA APGTSSGDAM
ALMENLASKL PAGIGYDWTG MSYQERLSGN QAPALVAISF VVVFLCLAAL YESWSIPVSV
MLVVPLGIVG VLLAATLFNQ KNDVYFMVGL LTTIGLSAKN AILIVEFAKD LMEKEGKGVV
EATLMAVRMR LRPILMTSLA FILGVLPLAI SNGAGSGAQN AVGIGVMGGM VSATLLAIFF
VPVFFVVIRR CFKG
Mol. Wt

111.45 kDa (calc) [2]

pI
Extinction coefficient

78730 - 79105 (calc based on 27 Y, 7 W, and 3 C residues)

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See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Domains/Motifs/Modification Sites

TypeResiduesDescriptionNotes

Domain

11 - 33

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

337 - 359

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

366 - 388

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

392 - 414

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

438 - 460

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

470 - 492

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

540 - 562

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

869 - 891

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

896 - 918

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

923 - 945

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

974 - 996

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

Domain

1006 - 1028

Predicted membrane-spanning helix.

TMD predicted by TMHMM[6]' />

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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

tmhmm.php?gene=acrF&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure

Structures
  • No results found.
Models

View models at:

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Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:ACRF-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P24181

UniProt (EcoliWiki Page)

UniProt:P24181

PFAM (EcoliWiki Page)

PFAM:PF00873

RefSeq (EcoliWiki Page)

RefSeq:NP_417732

ModBase (EcoliWiki Page)

ModBase:P24181

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:ACRF_2-MONOMER


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Notes

Links

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NameURLComments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ Daley DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308: 1321-3 PubMed EcoliWiki page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 Krogh A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305: 567-80 PubMed EcoliWiki page


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