Standard name	Ada
Synonyms	fused DNA-binding transcriptional dual regulator^[1], O6-methylguanine-DNA methyltransferase^[1], B2213^[2]^[1], Ada^[2]^[1]
Product description	Ada transcriptional dual regulator^[2]^[3]
EC number (for enzymes)	2.1.1.63^[1]
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Notes

Function

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Gene Ontology
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Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000005	C	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000002 GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR001497 InterPro:IPR008332 EC:2.1.1.63	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0003677	DNA binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004026 SP_KW:KW-0238	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0003700	transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000005	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014048	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000005	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006281	DNA repair	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR001497 InterPro:IPR004026 InterPro:IPR008332 InterPro:IPR014048 SP_KW:KW-0234	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006350	transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000005 InterPro:IPR004026 SP_KW:KW-0805	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0008168	methyltransferase activity	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004026 SP_KW:KW-0489	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0008270	zinc ion binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004026 SP_KW:KW-0862	F	Seeded from EcoCyc 12.5 ^[4]	complete
	GO:0005737	cytoplasm				C	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0016563	transcription activator activity				F	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0016564	transcription repressor activity				F	Seeded from EcoCyc 11.1^[3].	required fields missing
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Interactions

Partner Type	Partner	Notes	References
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Notes

Localization

Compartment	Description	Evidence	Notes
membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MKKATCLTDD QRWQSVLARD PNADGEFVFA VRTTGIFCRP SCRARHALRE NVSFYANASE ALAAGFRPCK RCQPEKANAQ QHRLDKITHA CRLLEQETPV TLEALADQVA MSPFHLHRLF KATTGMTPKA WQQAWRARRL RESLAKGESV TTSILNAGFP DSSSYYRKAD ETLGMTAKQF RHGGENLAVR YALADCELGR CLVAESERGI CAILLGDDDA TLISELQQMF PAADNAPADL MFQQHVREVI ASLNQRDTPL TLPLDIRGTA FQQQVWQALR TIPCGETVSY QQLANAIGKP KAVRAVASAC AANKLAIIIP CHRVVRGDGT LSGYRWGVSR KAQLLRREAE NEER
Mol. Wt	39.32 kDa (calc) ^[2]
pI	8.69^[2]
Extinction coefficient	36440 - 37940 (calc based on 6 Y, 5 W, and 12 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structures	Representative Escherichia coli structure: 1ZGW\|A 1-138 of 354 residues (E-value: 1.0e-71) (Percent Identity: 97.10) Representative homolog: 1WRJ\|A (Sulfolobus tokodaii) 60-146 of 354 residues (E-value: 1.6e-10) (Percent Identity: 38.89) View all other structures.
Models	View models at: EcoliPredict ModBase PSI-PRED Protein Quaternary Structure (PQS) Genomes TO Protein (GTOP)
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Structures

Representative Escherichia coli structure:
1ZGW|A
1-138 of 354 residues (E-value: 1.0e-71) (Percent Identity: 97.10)
Representative homolog:
1WRJ|A (Sulfolobus tokodaii)
60-146 of 354 residues (E-value: 1.6e-10) (Percent Identity: 38.89)
View all other structures.

Models

View models at:

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:PD00230
UniProt (EcoliWiki Page)	UniProt:P06134
PFAM (EcoliWiki Page)	PFAM:PF02805
RefSeq (EcoliWiki Page)	RefSeq:NP_416717
ModBase (EcoliWiki Page)	ModBase:P06134
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

ada:Gene Product(s)

From EcoliWiki

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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