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add:Gene Product(s)
From EcoliWiki
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
| Standard name |
Add |
|---|---|
| Synonyms | |
| Product description | |
| EC number (for enzymes) | |
| edit table |
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0009168 |
purine ribonucleoside monophosphate biosynthetic process |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001365 |
P |
Seeded from EcoCyc 12.5 [4] |
complete | ||
| GO:0009117 |
nucleotide metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0004000 |
adenosine deaminase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0019239 |
deaminase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0005737 |
cytoplasm |
C |
Seeded from Riley et al 2006 [1]. |
required fields missing | ||||
| GO:0015949 |
nucleobase, nucleoside and nucleotide interconversion |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0005488 |
binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
CHEBI:27834 (Deoxycoformycin mechanistically inhibits Add). |
complete | |||
| GO:0004000 |
adenosine deaminase activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
complete | ||||
| edit table |
Interactions
| Partner Type | Partner | Notes | References |
|---|---|---|---|
|
Small Molecule |
CHEBI:27834 (Deoxycoformycin) |
Inhibitor of Add activity |
|
| edit table |
See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Notes
Localization
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
| edit table |
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Notes
Structure and Physical Properties
Physical Properties
| Sequence |
MIDTTLPLTD IHRHLDGNIR PQTILELGRQ YNISLPAQSL ETLIPHVQVI ANEPDLVSFL TKLDWGVKVL ASLDACRRVA FENIEDAARH GLHYVELRFS PGYMAMAHQL PVAGVVEAVI DGVREGCRTF GVQAKLIGIM SRTFGEAACQ QELEAFLAHR DQITALDLAG DELGFPGSLF LSHFNRARDA GWHITVHAGE AAGPESIWQA IRELGAERIG HGVKAIEDRA LMDFLAEQQI GIESCLTSNI QTSTVAELAA HPLKTFLEHG IRASINTDDP GVQGVDIIHE YTVAAPAAGL SREQIRQAQI NGLEMAFLSA EEKRALREKV AAK |
|---|---|
| Mol. Wt |
36.4 kDa (calc) [2] |
| pI |
5.63[2] |
| Extinction coefficient |
22460 - 22960 (calc based on 4 Y, 3 W, and 4 C residues) |
| edit table |
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Domains/Motifs/Modification Sites
| Type | Residues | Description | Notes |
|---|---|---|---|
| edit table |
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
Structure
| Structures |
|
|---|---|
| Models |
View models at: |
| edit table |
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
Notes
Gene Product Resources
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Notes
Accessions in Other Databases
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
See Help:Product_accessions for help entering or editing information in this section of EcoliWiki.
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 4.2 4.3 4.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Frick L et al. (1986) Transition-state stabilization by adenosine deaminase: structural studies of its inhibitory complex with deoxycoformycin. Biochemistry 25: 1616-21 PubMed EcoliWiki page
- ↑ Wolfenden R et al. (1967) Substrate binding by adenosine deaminase. Specificity, pH dependence, and competition by mercurials. J Biol Chem 242: 977-83 PubMed EcoliWiki page
Categories
Categories: GO:0016787 ! hydrolase activity | GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process | GO:0009117 ! nucleotide metabolic process | GO:0004000 ! adenosine deaminase activity | GO:0019239 ! deaminase activity | GO:0005737 ! cytoplasm | GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion | GO:0005488 ! binding | Proteins
