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adhE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AdhE

Synonyms

fused acetaldehyde-CoA dehydrogenase[1], iron-dependent alcohol dehydrogenase[1], pyruvate-formate lyase deactivase[1], B1241[2][1], AdhC[2][1], Ana[2][1], AdhE[2][1]

Product description

AdhE[2][3];

Component of ADHE-CPLX[2]

Alcohol dehydrogenase, largely anaerobic; aerobic antioxidant; acetaldehyde-CoA dehydrogenase, CoA-linked; allyl alcohol resistance[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0003824

catalytic activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0511

F

Seeded from EcoCyc [5]

complete

GO:0004022

alcohol dehydrogenase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR012079
EC:1.1.1.1

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0046872

metal ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001670

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005506

iron ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0408

F

Seeded from EcoCyc [5]

complete

GO:0006066

alcohol metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012079

P

Seeded from EcoCyc [5]

complete

GO:0008152

metabolic process

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001670
InterPro:IPR015590

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0008774

acetaldehyde dehydrogenase (acetylating) activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR012079
EC:1.2.1.10

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0015976

carbon utilization

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012079

P

Seeded from EcoCyc [5]

complete

GO:0016491

oxidoreductase activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001670
InterPro:IPR015590
SP_KW:KW-0560

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:15690043[7]

IPI: Inferred from Physical Interaction

UniProtKB:P0A7V0

F

Seeded from EcoCyc [5]

complete

GO:0005624

membrane fraction

PMID:16858726[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

required fields missing

GO:0005739

mitochondrion

PMID:16858726[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [5]

complete

GO:0005829

cytosol

PMID:16858726[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [5]

complete

GO:0055114

oxidation reduction

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001670
InterPro:IPR018211
SP_KW:KW-0560

P

Seeded from EcoCyc [5]

complete

GO:0006113

fermentation

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0004022

alcohol dehydrogenase activity

PMID:6998946[9]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0008774

acetaldehyde dehydrogenase (acetylating) activity

PMID:6998946[9]

IMP: Inferred from Mutant Phenotype

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of ADHE-CPLX

could be indirect

Protein

nadE

PMID:16606699[10]

Experiment(s):EBI-1139291

Protein

lacZ

PMID:16606699[10]

Experiment(s):EBI-1139291

Protein

rpmB

PMID:16606699[10]

Experiment(s):EBI-1139291

Protein

intR

PMID:16606699[10]

Experiment(s):EBI-1139291

Protein

rplB

PMID:16606699[10]

Experiment(s):EBI-1139291

Protein

rsuA

PMID:16606699[10]

Experiment(s):EBI-1139291

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-891082

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MAVTNVAELN ALVERVKKAQ REYASFTQEQ VDKIFRAAAL AAADARIPLA KMAVAESGMG
IVEDKVIKNH FASEYIYNAY KDEKTCGVLS EDDTFGTITI AEPIGIICGI VPTTNPTSTA
IFKSLISLKT RNAIIFSPHP RAKDATNKAA DIVLQAAIAA GAPKDLIGWI DQPSVELSNA
LMHHPDINLI LATGGPGMVK AAYSSGKPAI GVGAGNTPVV IDETADIKRA VASVLMSKTF
DNGVICASEQ SVVVVDSVYD AVRERFATHG GYLLQGKELK AVQDVILKNG ALNAAIVGQP
AYKIAELAGF SVPENTKILI GEVTVVDESE PFAHEKLSPT LAMYRAKDFE DAVEKAEKLV
AMGGIGHTSC LYTDQDNQPA RVSYFGQKMK TARILINTPA SQGGIGDLYN FKLAPSLTLG
CGSWGGNSIS ENVGPKHLIN KKTVAKRAEN MLWHKLPKSI YFRRGSLPIA LDEVITDGHK
RALIVTDRFL FNNGYADQIT SVLKAAGVET EVFFEVEADP TLSIVRKGAE LANSFKPDVI
IALGGGSPMD AAKIMWVMYE HPETHFEELA LRFMDIRKRI YKFPKMGVKA KMIAVTTTSG
TGSEVTPFAV VTDDATGQKY PLADYALTPD MAIVDANLVM DMPKSLCAFG GLDAVTHAME
AYVSVLASEF SDGQALQALK LLKEYLPASY HEGSKNPVAR ERVHSAATIA GIAFANAFLG
VCHSMAHKLG SQFHIPHGLA NALLICNVIR YNANDNPTKQ TAFSQYDRPQ ARRRYAEIAD
HLGLSAPGDR TAAKIEKLLA WLETLKAELG IPKSIREAGV QEADFLANVD KLSEDAFDDQ
CTGANPRYPL ISELKQILLD TYYGRDYVEG ETAAKKEAAP AKAEKKAKKS A
Length

891

Mol. Wt

96.129 kDa

pI

6.8 (calculated)

Extinction coefficient

69,220 - 70,345 (calc based on 28 Y, 5 W, and 9 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed

UniProt:P0A9Q7


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rectanglemotifs

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:ADHE-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A9Q7

PFAM (EcoliWiki Page)

PFAM:PF00465

RefSeq (EcoliWiki Page)

RefSeq:NP_415757


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 6.3 6.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page
  8. ↑ 8.0 8.1 8.2 Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed EcoliWiki page
  9. ↑ 9.0 9.1 Clark DP & Cronan JE Jr (1980) Acetaldehyde coenzyme A dehydrogenase of Escherichia coli. J Bacteriol 144: 179-84 PubMed EcoliWiki page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page

Categories

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