amiC:Gene Product(s) - EcoliWiki
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amiC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

AmiC

Synonyms

N-acetylmuramoyl-L-alanine amidase[1], B2817[2][1], YgdN[2][1], AmiC[2][1]

Product description

N-acetylmuramyl-L-alanine amidase[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0009253

peptidoglycan catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002508

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR002508
EC:3.5.1.28

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0007047

cell wall organization

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0961

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0030288

outer membrane-bounded periplasmic space

C

Seeded from Riley et al 2006 [1].

required fields missing

GO:0009252

peptidoglycan biosynthetic process

PMID:11454209[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:amiA|EcoliWiki:amiB

P

Seeded from EcoCyc 11.1[3].

complete

GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0000910

cytokinesis

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0042597

periplasmic space

PMID:12787347[6]

IDA: Inferred from Direct Assay

C

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:11454209[5]

IDA: Inferred from Direct Assay

F

complete

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Interactions

Partner TypePartnerNotesReferences
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Notes

Localization

CompartmentDescriptionEvidenceNotes

periplasm


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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc

MTDYASFAKV SGQISRLLVT QLRFLLLGRG MSGSNTAISR RRLLQGAGAM WLLSVSQVSL
AAVSQVVAVR VWPASSYTRV TVESNRQLKY KQFALSNPER VVVDIEDVNL NSVLKGMAAQ
IRADDPFIKS ARVGQFDPQT VRMVFELKQN VKPQLFALAP VAGFKERLVM DLYPANAQDM
QDPLLALLED YNKGDLEKQV PPAQSGPQPG KAGRDRPIVI MLDPGHGGED SGAVGKYKTR
EKDVVLQIAR RLRSLIEKEG NMKVYMTRNE DIFIPLQVRV AKAQKQRADL FVSIHADAFT
SRQPSGSSVF ALSTKGATST AAKYLAQTQN ASDLIGGVSK SGDRYVDHTM FDMVQSLTIA
DSLKFGKAVL NKLGKINKLH KNQVEQAGFA VLKAPDIPSI LVETAFISNV EEERKLKTAT
FQQEVAESIL AGIKAYFADG ATLARRG
Mol. Wt

45.63 kDa (calc) [2]

pI
Extinction coefficient

25900 (calc based on 10 Y, 2 W, and 0 C residues)

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Domains/Motifs/Modification Sites

TypeResiduesDescriptionNotes

motif

1-31

UniProt Manual:Signal Peptides

UniProt:P63883

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Structure

Structures
  • Representative homolog:
    1JWQ|A (Paenibacillus polymyxa)
    3-120 of 447 residues (E-value: 6.3e-22) (Percent Identity: 33.90)
  • View all other structures.
Models

View models at:

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Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G7458-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P63883

UniProt (EcoliWiki Page)

UniProt:P63883

PFAM (EcoliWiki Page)

PFAM:PF01520

RefSeq (EcoliWiki Page)

RefSeq:NP_417294

ModBase (EcoliWiki Page)

ModBase:P63883


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Notes

Links

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NameURLComments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 4.2 4.3 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. 5.0 5.1 Heidrich C et al. (2001) Involvement of N-acetylmuramyl-L-alanine amidases in cell separation and antibiotic-induced autolysis of Escherichia coli. Mol Microbiol 41: 167-78 PubMed EcoliWiki page
  6. Bernhardt TG & de Boer PA (2003) The Escherichia coli amidase AmiC is a periplasmic septal ring component exported via the twin-arginine transport pathway. Mol Microbiol 48: 1171-82 PubMed EcoliWiki page


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