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araD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AraD

Synonyms

L-ribulose-5-phosphate 4-epimerase[1], B0061[2][1], AraD[2][1]

Product description

L-ribulose-phosphate 4-epimerase[2][3];

Component of L-ribulose-phosphate 4-epimerase[2][3]

L-ribulose-5-phosphate 4-epimerase[4]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0046872

metal ion binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001303
SP_KW:KW-0479

F

Seeded from EcoCyc [5]

complete

GO:0008742

L-ribulose-phosphate 4-epimerase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR004661
EC:5.1.3.4

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0008270

zinc ion binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004661
SP_KW:KW-0862

F

Seeded from EcoCyc [5]

complete

GO:0008742

L-ribulose-phosphate 4-epimerase activity

PMID:9548961[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0019324

L-lyxose metabolic process

PMID:10913097[8]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [5]

complete

GO:0019569

L-arabinose catabolic process to xylulose 5-phosphate

PMID:7768852[9]

IEP: Inferred from Expression Pattern

P

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005975

carbohydrate metabolic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0119

P

Seeded from EcoCyc [5]

complete

GO:0016853

isomerase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0413

F

Seeded from EcoCyc [5]

complete

GO:0019568

arabinose catabolic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0054

P

Seeded from EcoCyc [5]

complete

GO:0019572

L-arabinose catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004661

P

Seeded from EcoCyc [5]

complete

GO:0016052

carbohydrate catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of L-ribulose-phosphate 4-epimerase

could be indirect

Protein

rhsE

PMID:16606699[10]

Experiment(s):EBI-1135466

Protein

aceB

PMID:16606699[10]

Experiment(s):EBI-1135466

Protein

parE

PMID:16606699[10]

Experiment(s):EBI-1135466

Protein

yjiR

PMID:16606699[10]

Experiment(s):EBI-1135466

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MLEDLKRQVL EANLALPKHN LVTLTWGNVS AVDRERGVFV IKPSGVDYSV MTADDMVVVS
IETGEVVEGT KKPSSDTPTH RLLYQAFPSI GGIVHTHSRH ATIWAQAGQS IPATGTTHAD
YFYGTIPCTR KMTDAEINGE YEWETGNVIV ETFEKQGIDA AQMPGVLVHS HGPFAWGKNA
EDAVHNAIVL EEVAYMGIFC RQLAPQLPDM QQTLLDKHYL RKHGAKAYYG Q
Length

231

Mol. Wt

25.517 kDa

pI

6.6 (calculated)

Extinction coefficient

35,410 - 35,660 (calc based on 9 Y, 4 W, and 2 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences


rectanglerectanglerectanglemotifs

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:RIBULPEPIM-MONOMER

UniProt (EcoliWiki Page)

UniProt:P08203

PFAM (EcoliWiki Page)

PFAM:PF00596

RefSeq (EcoliWiki Page)

RefSeq:NP_414603


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. 6.0 6.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. Johnson AE & Tanner ME (1998) Epimerization via carbon-carbon bond cleavage. L-ribulose-5-phosphate 4-epimerase as a masked class II aldolase. Biochemistry 37: 5746-54 PubMed EcoliWiki page
  8. Ibañez E et al. (2000) Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose. J Bacteriol 182: 4625-7 PubMed EcoliWiki page
  9. Johnson CM & Schleif RF (1995) In vivo induction kinetics of the arabinose promoters in Escherichia coli. J Bacteriol 177: 3438-42 PubMed EcoliWiki page
  10. 10.0 10.1 10.2 10.3 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page

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