Standard name	ArcA product
Synonyms	B4401 product^[1], negative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA) product^[1], CpxC product^[1], Dye product^[1], FexA product^[1], Msp product^[1], Seg product^[1], SfrA product^[1], respiration control protein ArcA product^[1], unphosphorylated respiration control protein ArcA product^[1], unmodified respiration control protein ArcA product^[1], ArcA control protein product^[1], dye resistance protein product^[1], aerobic respiration control protein ArcA product^[1]
Product description	ArcA transcriptional dual regulator^[1]^[2] DNA-binding response regulator in two-component regulatory system with ArcB or CpxA product
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003677	DNA binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR001867 SP_KW:KW-0238	F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0000156	two-component response regulator activity	GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001789 InterPro:IPR001867	F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR001789 InterPro:IPR001867 SP_KW:KW-902	P	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0006350	transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR001789 InterPro:IPR001867 SP_KW:KW-0805	P	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A717	F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0006350	transcription	PMID:16849788^[5]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0006350	transcription	PMID:16849788^[5]	IEP: Inferred from Expression Pattern		P	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0016563	transcription activator activity	PMID:16849788^[5]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0016563	transcription activator activity	PMID:16849788^[5]	IEP: Inferred from Expression Pattern		F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0016564	transcription repressor activity	PMID:16849788^[5]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0016564	transcription repressor activity	PMID:16849788^[5]	IEP: Inferred from Expression Pattern		F	Seeded from EcoCyc 12.5 ^[3]	complete
	GO:0006979	response to oxidative stress				P	Seeded from EcoCyc 11.1^[2].	required fields missing
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Interactions

Partner Type	Partner	Notes	References
Protein	ArcB	ArcA and ArcB are cognate response regulator and sensor kinase, respectively.
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Notes

Phosphorylation required for DNA binding

Localization

Compartment	Description	Evidence	Notes
cytoplasm			From EcoCyc^[2]
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MQTPHILIVE DELVTRNTLK SIFEAEGYDV FEATDGAEMH QILSEYDINL VIMDINLPGK NGLLLARELR EQANVALMFL TGRDNEVDKI LGLEIGADDY ITKPFNPREL TIRARNLLSR TMNLGTVSEE RRSVESYKFN GWELDINSRS LIGPDGEQYK LPRSEFRAML HFCENPGKIQ SRAELLKKMT GRELKPHDRT VDVTIRRIRK HFESTPDTPE IIATIHGEGY RFCGDLED
Mol. Wt	27.29 kDa (calc) ^[1]
pI	5.16^[1]
Extinction coefficient	14440 - 14690 (calc based on 6 Y, 1 W, and 2 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
Domain	1 - 118	Response regulatory	UniProt:P0A9Q1
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Structure

Structures	Representative Escherichia coli structure: 1XHF\|A 2-121 of 238 residues (E-value: 7.9e-58) (Percent Identity: 97.50) Representative homolog: 3CZ5\|A (Aurantimonas sp. SI85-9A1) 3-141 of 238 residues (E-value: 1.0e-11) (Percent Identity: 28.78) View all other structures.
Models	View models at: EcoliPredict ModBase PSI-PRED Protein Quaternary Structure (PQS) Genomes TO Protein (GTOP)
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Structures

Representative Escherichia coli structure:
1XHF|A
2-121 of 238 residues (E-value: 7.9e-58) (Percent Identity: 97.50)
Representative homolog:
3CZ5|A (Aurantimonas sp. SI85-9A1)
3-141 of 238 residues (E-value: 1.0e-11) (Percent Identity: 28.78)
View all other structures.

Models

View models at:

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:PHOSPHO-ARCA
UniProt (EcoliWiki Page)	UniProt:P0A9Q1
PFAM (EcoliWiki Page)	PFAM:PF00072
RefSeq (EcoliWiki Page)	RefSeq:NP_418818
ModBase (EcoliWiki Page)	ModBase:P0A9Q1
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^2.0 ^2.1 ^2.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Cho BK et al. (2006) Transcriptional regulation of the fad regulon genes of Escherichia coli by ArcA. Microbiology 152: 2207-19 PubMed EcoliWiki page

arcA:Gene Product(s)

From EcoliWiki

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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