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References Suggestions

Standard Name


Gene Synonym(s)

ECK2912, b2916, JW2883, iciA[1][2], can, canR, iciA

Product Desc.

ArgP transcriptional activator[3][4]

Arginine and lysine responsive transcriptional regulator; inhibitor of chromosome initiation; positive regulator of argK, negative autoregulator in presence of arginine; oriC iteron (13-mer) binding protein, competes with DnaA for iteron binding; activate[5]

Product Synonyms(s)

DNA-binding transcriptional activator, replication initiation inhibitor[1], B2916[3][1], ArgP[3][1], IciA[3][1][2] , can, canR, ECK2912, iciA, JW2883, b2916

Function from GO

Molecular Function

Biological Process

Knock-Out Phenotype

transcription unit(s): argP[3], iciA

Quick Links

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ArgP(IciA) is a LysR family transcriptional regulator. argP mutants are canavanine sensitive. argP is in the pho regulon. ArgP activates the dapB gene in te absense of lysine (Bouvier, 2008).[5]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 Celis, RT (1999) Repression and activation of arginine transport genes in Escherichia coli K 12 by the ArgP protein. J. Mol. Biol. 294 1087-95 PubMed EcoliWiki page
  3. 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. 5.0 5.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.