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Standard Name

arnA

Gene Synonym(s)

yfbG, ECK2248, b2255, JW2249, pmrI, SAF[1][2], pbgP3, SAF

Product Desc.

G7168[2][3]

UDP-glucuronate dehydrogenase and UDP-ara4N formyltransferase[4]

Product Synonyms(s)

fused UDP-L-Ara4N formyltransferase[1], UDP-GlcA C-4'-decarboxylase[1], B2255[2][1], ArnA[2][1], YfbG[2][1], PmrI[2][1] , ECK2248, JW2249, pbgP3, pmrI, SAF, yfbG, b2255

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yfbE[2]

Regulation/Activity
Quick Links

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Notes

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Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. This bifunctional enzyme catalyzes two steps in lipid A phosphate group modification by aminoarabinose. The C-terminal 345-residues encode the NAD+-dependent dehydrogenase domain that catalyzes the first step in UDP-4-amino-4-deoxy-L-arabinose synthesis and involves successive C4 oxidation and C6 decarboxylation steps. The N-terminal 304-residue domain encodes N-10 formyltetrahydrofolate-dependent UDP-aminoarabinose N-formyltransferase (UDP-formamidoarabinose synthase) that makes the substrate for ArnC: UDP-ara4FN = uridine 5'-diphospho-beta-(4-deoxy-4-formamido-L-arabinose). ArnA is identical to ssrA-associated factor SAF. basRS regulon.[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.