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aroC:On One Page

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Standard Name

aroC

Gene Synonym(s)

ECK2323, b2329, JW2326[1]

Product Desc.

AroC[2][3];

Component of chorismate synthase[2][3]

Chorismate synthase[4]

Product Synonyms(s)

chorismate synthase[1], B2329[2][1], AroC[2][1]

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yfcL[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(aroC)    Textpresso(aroC)

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

aroC

Mnemonic

Aromatic

Synonyms

ECK2323, b2329, JW2326[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

52.68 minutes 

MG1655: 2445495..2444410
gbrowse_img.php?coord=2444410..2445495&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 2391065..2389980
gbrowse_img.php?coord=2389980..2391065&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 2452919..2451834
gbrowse_img.php?coord=2451834..2452919&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 2537260..2536175
gbrowse_img.php?coord=2536175..2537260&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 2330215..2331300
gbrowse_img.php?coord=2330215..2331300&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔaroC (Keio:JW2326)

deletion

deletion

PMID:16738554

Shigen
CGSC9865[5]

aroC

PMID:12519969

ASAP

At position 619 in Plus orientation, contains plasmid pKD46.
ASAP strain name: FB20766

aroC

PMID:12519969

ASAP

At position 619 in Plus orientation, does not contain plasmid pKD46.
ASAP strain name: FB20767

aroC4

CGSC:6010

aroC355

CGSC:8228

aroC1

PMID:5326114 PMID:14221874

CGSC:13158

aroC8

CGSC:17181

ΔaroC737::kan

PMID:16738554

CGSC:100062


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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW2326

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCGCTGGAAACACAATTGGACA

Primer 2:CCCCAGCGTGGAATATCAGTCTT

zfb-223::Tn10

Linked marker

CAG18484 = CGSC7406[5]

est. P1 cotransduction: 7% [6]
Synonyms:zej-223::Tn10

zfd-1::Tn10

Linked marker

CAG18467 = CGSC7408[5]

est. P1 cotransduction: 12% [6]
Synonyms:zfb-1::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10075

EchoBASE (EcoliWiki Page)

EchoBASE:EB0073

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b2329

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C2875

EcoGene (EcoliWiki Page)

EcoGene:EG10075

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:AROC

CGSC (EcoliWiki Page)

CGSC:1006

ASAP (EcoliWikiPage)

ASAP:ABE-0007693


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AroC

Synonyms

chorismate synthase[1], B2329[2][1], AroC[2][1]

Product description

AroC[2][3];

Component of chorismate synthase[2][3]

Chorismate synthase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0016829

lyase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc [7]

complete

GO:0008652

amino acid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0028

P

Seeded from EcoCyc [7]

complete

GO:0009073

aromatic amino acid family biosynthetic process

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR000453
SP_KW:KW-0057
HAMAP:MF_00300

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0004107

chorismate synthase activity

GO_REF:0000002
GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR000453
EC:4.2.3.5
HAMAP:MF_00300

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

required fields missing

GO:0009423

chorismate biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of chorismate synthase

could be indirect

Protein

cobS

PMID:16606699

Experiment(s):EBI-1142581

Protein

yfhM

PMID:16606699

Experiment(s):EBI-1142581

Protein

dnaC

PMID:16606699

Experiment(s):EBI-1142581

Protein

yghA

PMID:16606699

Experiment(s):EBI-1142581

Protein

mukB

PMID:16606699

Experiment(s):EBI-1142581

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MAGNTIGQLF RVTTFGESHG LALGCIVDGV PPGIPLTEAD LQHDLDRRRP GTSRYTTQRR
EPDQVKILSG VFEGVTTGTS IGLLIENTDQ RSQDYSAIKD VFRPGHADYT YEQKYGLRDY
RGGGRSSARE TAMRVAAGAI AKKYLAEKFG IEIRGCLTQM GDIPLDIKDW SQVEQNPFFC
PDPDKIDALD ELMRALKKEG DSIGAKVTVV ASGVPAGLGE PVFDRLDADI AHALMSINAV
KGVEIGDGFD VVALRGSQNR DEITKDGFQS NHAGGILGGI SSGQQIIAHM ALKPTSSITV
PGRTINRFGE EVEMITKGRH DPCVGIRAVP IAEAMLAIVL MDHLLRQRAQ NADVKTDIPR W
Length

361

Mol. Wt

39.137 kDa

pI

6.1 (calculated)

Extinction coefficient

21,430 - 21,930 (calc based on 7 Y, 2 W, and 4 C residues)

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Domains/Motifs/Modification Sites

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TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed

UniProt:P12008


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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:AROC-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P12008

UniProt (EcoliWiki Page)

UniProt:P12008

PFAM (EcoliWiki Page)

PFAM:PF01264

RefSeq (EcoliWiki Page)

RefSeq:NP_416832


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

yfcL

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=2445475..2445515&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein+flip&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b2329 (EcoliWiki Page)

NCBI GEO profiles for aroC

microarray

GenExpDB:b2329 (EcoliWiki Page)

Summary of data for aroC from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to aroC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10075

EchoBASE (EcoliWiki Page)

EchoBASE:EB0073

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b2329

EcoGene (EcoliWiki Page)

EcoGene:EG10075


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Arabidopsis thaliana

  • AT1G48850 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Oryza gramene

  • Q75W14 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YGL148W (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPCC12234 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

AROC

From SHIGELLACYC

E. coli O157

AROC

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF01264


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

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