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Standard Name

bcsA

Gene Synonym(s)

ECK3518, b3533, JW5665, yhjO, yhjP, yhjOP[1]

Product Desc.

putative cellulose synthase, joins former yhjO and yhjP[2]; cellulose synthase, catalytic subunit[3]

Celullose synthase, catalytic subunit; inner membrane protein[4]

Product Synonyms(s)

cellulose synthase, catalytic subunit[1], B3533[2][1], YhjO[2][1], YhjP[2][1], BcsA[2][1]

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): bcsABZC[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(bcsA)    Textpresso(bcsA)

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Notes

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BcsA has a C-terminal PilZ domain, which has been implicated in cyclic-di-GMP binding to YcgR.[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

bcsA

Mnemonic

Bacterial cellulose synthesis

Synonyms

ECK3518, b3533, JW5665, yhjO, yhjP, yhjOP[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

79.55 minutes 

MG1655: 3693259..3690641
gbrowse_img.php?coord=3690641..3693259&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 3622110..3624728
gbrowse_img.php?coord=3622110..3624728&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 3945179..3947797
gbrowse_img.php?coord=3945179..3947797&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 3791004..3788386
gbrowse_img.php?coord=3788386..3791004&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 3579135..3581753
gbrowse_img.php?coord=3579135..3581753&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔbcsA (Keio:JW5665)

deletion

deletion

PMID:16738554

Shigen
CGSC11507[5]

yhjOP::Tn5KAN

PMID:12519969

ASAP

At position 610 in Plus orientation, contains plasmid pKD46.
ASAP strain name: FB21259

ΔbcsA787::kan

PMID:16738554

CGSC:100162


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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW5665

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCAGTATCCTGACCCGGTGGTT

Primer 2:CCTTGTTGAGCCAAAGCCTGATC

zhg-50::Tn10

Linked marker

CAG18450 = CGSC7450[5]

est. P1 cotransduction: % [6]
Synonyms:zhf-50::Tn10, zhf-5::Tn10

zic-4901::Tn10

Linked marker

CAG18492 = CGSC7457[5]

est. P1 cotransduction: % [6]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG12260

EchoBASE (EcoliWiki Page)

EchoBASE:EB2169

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b3533

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C4345

EcoGene (EcoliWiki Page)

EcoGene:EG12260

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:YHJOP

ASAP (EcoliWikiPage)

ASAP:ABE-0011547


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

BcsA

Synonyms

cellulose synthase, catalytic subunit[1], B3533[2][1], YhjO[2][1], YhjP[2][1], BcsA[2][1]

Product description

putative cellulose synthase, joins former yhjO and yhjP[2]; cellulose synthase, catalytic subunit[3]

Celullose synthase, catalytic subunit; inner membrane protein[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0006011

UDP-glucose metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003919

P

Seeded from EcoCyc [7]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003919
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [8]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc [7]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [7]

complete

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0328

F

Seeded from EcoCyc [7]

complete

GO:0016759

cellulose synthase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003919

F

Seeded from EcoCyc [7]

complete

GO:0016760

cellulose synthase (UDP-forming) activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.4.1.12

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0030244

cellulose biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0135

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [7]

complete

GO:0005887

integral to plasma membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017480

C

Seeded from EcoCyc [7]

complete

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MPVELLRAEN ASRECIMSIL TRWLLIPPVN ARLIGRYRDY RRHGASAFSA TLGCFWMILA
WIFIPLEHPR WQRIRAEHKN LYPHINASRP RPLDPVRYLI QTCWLLIGAS RKETPKPRRR
AFSGLQNIRG RYHQWMNELP ERVSHKTQHL DEKKELGHLS AGARRLILGI IVTFSLILAL
ICVTQPFNPL AQFIFLMLLW GVALIVRRMP GRFSALMLIV LSLTVSCRYI WWRYTSTLNW
DDPVSLVCGL ILLFAETYAW IVLVLGYFQV VWPLNRQPVP LPKDMSLWPS VDIFVPTYNE
DLNVVKNTIY ASLGIDWPKD KLNIWILDDG GREEFRQFAQ NVGVKYIART THEHAKAGNI
NNALKYAKGE FVSIFDCDHV PTRSFLQMTM GWFLKEKQLA MMQTPHHFFS PDPFERNLGR
FRKTPNEGTL FYGLVQDGND MWDATFFCGS CAVIRRKPLD EIGGIAVETV TEDAHTSLRL
HRRGYTSAYM RIPQAAGLAT ESLSAHIGQR IRWARGMVQI FRLDNPLTGK GLKFAQRLCY
VNAMFHFLSG IPRLIFLTAP LAFLLLHAYI IYAPALMIAL FVLPHMIHAS LTNSKIQGKY
RHSFWSEIYE TVLAWYIAPP TLVALINPHK GKFNVTAKGG LVEEEYVDWV ISRPYIFLVL
LNLVGVAVGI WRYFYGPPTE MLTVVVSMVW VFYNLIVLGG AVAVSVESKQ VRRSHRVEMT
MPAAIAREDG HLFSCTVQDF SDGGLGIKIN GQAQILEGQK VNLLLKRGQQ EYVFPTQVAR
VMGNEVGLKL MPLTTQQHID FVQCTFARAD TWALWQDSYP EDKPLESLLD ILKLGFRGYR
HLAEFAPSSV KGIFRVLTSL VSWVVSFIPR RPERSETAQP SDQALAQQ
Length

888

Mol. Wt

101.6 kDa

pI

9.8 (calculated)

Extinction coefficient

187,700 - 189,200 (calc based on 30 Y, 26 W, and 12 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences
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tmhmm.php?gene=bcsA&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG12260-MONOMER

UniProt (EcoliWiki Page)

UniProt:P37653

PFAM (EcoliWiki Page)

PFAM:PF00535

RefSeq (EcoliWiki Page)

RefSeq:NP_417990


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

bcsABZC

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=3693239..3693279&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein+flip&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b3533 (EcoliWiki Page)

NCBI GEO profiles for bcsA

microarray

GenExpDB:b3533 (EcoliWiki Page)

Summary of data for bcsA from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to bcsA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG12260

EchoBASE (EcoliWiki Page)

EchoBASE:EB2169

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b3533

EcoGene (EcoliWiki Page)

EcoGene:EG12260


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Arabidopsis thaliana

  • AT5G22740 (score: 1.000; bootstrap: 64%)
  • AT5G03760 (score: 0.716)
  • AT1G23480 (score: 0.622)
  • AT4G13410 (score: 0.597)
  • AT2G35650 (score: 0.592)
  • AT1G24070 (score: 0.560)
  • AT5G16190 (score: 0.533)
  • AT3G56000 (score: 0.532)
  • AT4G16590 (score: 0.440)
  • AT3G28180 (score: 0.336)
  • AT4G31590 (score: 0.334)
  • AT2G24630 (score: 0.324)
  • AT4G07960 (score: 0.321)
  • AT3G07330 (score: 0.317)

From Inparanoid:20070104

Oryza gramene

  • Q7EZW6 (score: 1.000; bootstrap: 100%)
  • Q7PC66 (score: 0.992)
  • Q9LHZ7 (score: 0.642)
  • Q8W3F9 (score: 0.589)
  • Q5Z6E5 (score: 0.541)
  • Q84UP7 (score: 0.307)
  • Q6S353 (score: 0.296)
  • Q4U0Z5 (score: 0.292)
  • Q9LLI1 (score: 0.291)
  • Q84M43 (score: 0.290)
  • Q67BC7 (score: 0.290)
  • Q4U0Z6 (score: 0.289)
  • Q75RZ1 (score: 0.287)
  • Q9LLI5 (score: 0.286)
  • Q6S354 (score: 0.286)
  • Q6S352 (score: 0.285)
  • Q851L8 (score: 0.284)
  • Q6UDF1 (score: 0.281)
  • Q9AV71 (score: 0.280)
  • Q6S349 (score: 0.275)
  • Q6AT26 (score: 0.275)
  • Q69P51 (score: 0.275)
  • Q4U101 (score: 0.274)
  • Q4U100 (score: 0.274)
  • Q9LLI9 (score: 0.274)
  • Q4U0Z9 (score: 0.274)
  • Q4U0Z2 (score: 0.274)
  • Q9LLI6 (score: 0.272)
  • Q84ZN6 (score: 0.272)
  • Q9LLI8 (score: 0.272)
  • Q6YVM4 (score: 0.271)
  • Q944E1 (score: 0.270)
  • Q84S11 (score: 0.270)
  • Q69V23 (score: 0.269)
  • Q9LLI3 (score: 0.267)
  • Q944E2 (score: 0.266)
  • Q6ZF89 (score: 0.266)
  • Q9LLI4 (score: 0.266)
  • Q9LLI2 (score: 0.266)
  • Q944D9 (score: 0.265)
  • Q6ZF86 (score: 0.265)
  • Q4U0Z4 (score: 0.263)
  • Q84S18 (score: 0.262)
  • Q4U0Z8 (score: 0.261)
  • Q5JN63 (score: 0.257)
  • Q67BC8 (score: 0.255)
  • Q9LLI7 (score: 0.251)
  • Q4U0Z7 (score: 0.247)
  • Q6S351 (score: 0.247)
  • Q7XHV0 (score: 0.244)
  • Q4U0Z3 (score: 0.242)
  • Q944E0 (score: 0.238)
  • Q6ZF85 (score: 0.238)
  • Q94GM9 (score: 0.212)
  • Q7XFJ8 (score: 0.212)
  • Q69XK5 (score: 0.155)
  • Q8W1N5 (score: 0.138)
  • Q6S350 (score: 0.126)
  • Q8W1N4 (score: 0.121)
  • O48961 (score: 0.111)
  • Q651X8 (score: 0.098)
  • Q651X6 (score: 0.096)
  • Q944E4 (score: 0.092)
  • Q7PC71 (score: 0.090)
  • Q7XUT9 (score: 0.090)
  • Q7PC72 (score: 0.088)
  • Q8W1N3 (score: 0.087)
  • Q8LMB4 (score: 0.085)
  • Q8W1M8 (score: 0.085)
  • Q944E3 (score: 0.084)
  • Q8W1N0 (score: 0.082)
  • Q7EYE9 (score: 0.080)
  • Q6S348 (score: 0.075)
  • Q651X7 (score: 0.074)
  • Q7XUU0 (score: 0.054)

From Inparanoid:20070104

E. coli O157

YHJOP

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00535


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 8.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

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