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References Suggestions

Standard Name


Gene Synonym(s)

ycfR, ECK1098, b1112, JW1098[1][2], JW1098

Product Desc.

conserved hypothetical protein[3]; protein involved in stress resistance and biofilm formation[2]

Biofilm, cell surface and signaling defects, member of YhcN Family; molecular and physiological function unknown[4]

Product Synonyms(s)

predicted protein[1], B1112[3][1], YcfR[3][1], BhsA[2][1] , ECK1098, JW1098, ycfR, b1112

Function from GO
Knock-Out Phenotype

transcription unit(s): ycfR[3]

Quick Links

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Complex mutant phenotype includes sensitivity to acid, heat, hydrogen peroxide, and cadmium, as well as 5-fold increased biofilm in the presence of glucose, increased cell surface hydrophobicity, and increased aggregation; the mutant phenotype of enhanced biofilm formation upon stress is suppressed by exogenous indole or by a tnaA mutation (Zhang, 2007). Induced during biofilm formation. Crp regulon. Probable periplasmic protein. The first 22 aa are predicted to be a type I signal peptide.[4]

BhsA (YcfR) is a member of the YhcN_Family of paralogs.[5]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Rudd, KE et al. (1998) Low molecular weight proteins: a challenge for post-genomic research. Electrophoresis 19 536-44 PubMed EcoliWiki page