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cheY:Quickview

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References Suggestions

Standard Name

cheY

Gene Synonym(s)

ECK1883, b1882, JW1871[1], JW1871

Product Desc.

chemotaxis regulator transmitting signal to flagellar motor component[1]

Response regulator for chemotactic signal transduction; CheA is the cognate sensor protein[2]

Product Synonyms(s)

B1882[3][1], ECK1883, JW1871, b1882

Function from GO

Biological Process

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): tar-tap-cheRBYZ[3]

Regulation/Activity
Quick Links

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dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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CheY is acetylated at lysine residues 92 and 109 by acetyl-CoA synthase (Acs). Proposed mechanism for optimum chemotaxis suggests alteration of side chain signaling state by rotation of Tyr106 side chain; this is presumably modulated by phosphorylation state of the molecule. A mutation resulting in a tyrosine to tryptophan substitution at position 106 results in a hyperactive phenotype, while a double mutation T87I/Y106W resulted in loss of activity. Substitutions at ILE95 affect FliM binding. Flagellar regulon.[2]



References

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  1. 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. 3.0 3.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7