|Quickview||Gene||Gene Product(s)||Expression||Evolution||On One Page|
ECK1883, b1882, JW1871, JW1871
chemotaxis regulator transmitting signal to flagellar motor component
Response regulator for chemotactic signal transduction; CheA is the cognate sensor protein
|Function from GO||
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CheY is acetylated at lysine residues 92 and 109 by acetyl-CoA synthase (Acs). Proposed mechanism for optimum chemotaxis suggests alteration of side chain signaling state by rotation of Tyr106 side chain; this is presumably modulated by phosphorylation state of the molecule. A mutation resulting in a tyrosine to tryptophan substitution at position 106 results in a hyperactive phenotype, while a double mutation T87I/Y106W resulted in loss of activity. Substitutions at ILE95 affect FliM binding. Flagellar regulon.
- Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7