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clpA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ClpA

Synonyms

ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity[1], B0882[2][1], LopD[2][1], CipA[2][1], ClpA[2][1]

Product description

ATP-binding component of serine protease[2][3];

Component of ClpA ATP-dependent protease specificity component and chaperone[3]; ClpAXP[3]; ClpAP[3]

ATPase subunit of ClpAP ATP-dependent protease; protease Ti; molecular chaperone[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc [5]

complete

GO:0019538

protein metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004176

P

Seeded from EcoCyc [5]

complete

GO:0000166

nucleotide binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003593
SP_KW:KW-0547

F

Seeded from EcoCyc [5]

complete

GO:0005515

protein binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004176

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005524

ATP binding

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001270
InterPro:IPR003959
SP_KW:KW-0067

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:12235156[7]

IPI: Inferred from Physical Interaction

UniProtKB:P0A8Q6

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0006457

protein folding

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009050

glycopeptide catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0006508

proteolysis

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of ClpA ATP-dependent protease specificity component and chaperone

could be indirect

Protein

mukB

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

rho

PMID:15690043[8]

Experiment(s):EBI-884758, EBI-891593

Protein

rplE

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

rplJ

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

rpoB

PMID:15690043[8]

Experiment(s):EBI-884758, EBI-879304

Protein

rpoC

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

rpsA

PMID:15690043[8]

Experiment(s):EBI-884758, EBI-891593

Protein

rpsB

PMID:15690043[8]

Experiment(s):EBI-884758, EBI-891593

Protein

rpsD

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

rpsG

PMID:15690043[8]

Experiment(s):EBI-884758, EBI-891593

Protein

secA

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

spoT

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

tufA

PMID:15690043[8]

Experiment(s):EBI-884758

Protein

rpsF

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpsJ

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpsN

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpsP

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpsU

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

sbcC

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

ybjE

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

ygiF

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

yhbY

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

clpS

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

barA

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

dnaK

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

proV

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

purL

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rhsC

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rplC

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rplI

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rplL

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rplM

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rplR

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rplU

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpmA

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpmC

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

rpmG

PMID:15690043[8]

Experiment(s):EBI-891593

Protein

ybaA

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

fdnH

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

ppk

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

rplB

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

fhuA

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

yciH

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

cadA

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

cheY

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

nadE

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

rplQ

PMID:16606699[9]

Experiment(s):EBI-1138254

Protein

Subunits of ClpAXP

could be indirect

Protein

Subunits of ClpAP

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MLNQELELSL NMAFARAREH RHEFMTVEHL LLALLSNPSA REALEACSVD LVALRQELEA
FIEQTTPVLP ASEEERDTQP TLSFQRVLQR AVFHVQSSGR NEVTGANVLV AIFSEQESQA
AYLLRKHEVS RLDVVNFISH GTRKDEPTQS SDPGSQPNSE EQAGGEERME NFTTNLNQLA
RVGGIDPLIG REKELERAIQ VLCRRRKNNP LLVGESGVGK TAIAEGLAWR IVQGDVPEVM
ADCTIYSLDI GSLLAGTKYR GDFEKRFKAL LKQLEQDTNS ILFIDEIHTI IGAGAASGGQ
VDAANLIKPL LSSGKIRVIG STTYQEFSNI FEKDRALARR FQKIDITEPS IEETVQIING
LKPKYEAHHD VRYTAKAVRA AVELAVKYIN DRHLPDKAID VIDEAGARAR LMPVSKRKKT
VNVADIESVV ARIARIPEKS VSQSDRDTLK NLGDRLKMLV FGQDKAIEAL TEAIKMARAG
LGHEHKPVGS FLFAGPTGVG KTEVTVQLSK ALGIELLRFD MSEYMERHTV SRLIGAPPGY
VGFDQGGLLT DAVIKHPHAV LLLDEIEKAH PDVFNILLQV MDNGTLTDNN GRKADFRNVV
LVMTTNAGVR ETERKSIGLI HQDNSTDAME EIKKIFTPEF RNRLDNIIWF DHLSTDVIHQ
VVDKFIVELQ VQLDQKGVSL EVSQEARNWL AEKGYDRAMG ARPMARVIQD NLKKPLANEL
LFGSLVDGGQ VTVALDKEKN ELTYGFQSAQ KHKAEAAH
Length

758

Mol. Wt

84.207 kDa

pI

6.3 (calculated)

Extinction coefficient

32,890 - 33,265 (calc based on 11 Y, 3 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10156-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0ABH9

PFAM (EcoliWiki Page)

PFAM:PF02861

RefSeq (EcoliWiki Page)

RefSeq:NP_415403


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Guo F et al. (2002) Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA. J Biol Chem 277: 46753-62 PubMed EcoliWiki page
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 8.22 8.23 8.24 8.25 8.26 8.27 8.28 8.29 8.30 8.31 8.32 8.33 8.34 8.35 8.36 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page

Categories

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