clpX:Gene Product(s)

Standard name	ClpX
Synonyms	ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease^[1], B0438^[2]^[1], LopC^[2]^[1]
Product description	ClpX^[2]^[3]; Component of ClpX ATP-dependent protease specificity component and chaperone^[3]; ClpAXP^[3]; ClpXP^[3] ATPase subunit of ClpXP protease; ClpXP degrades ssrA-tagged proteins; molecular chaperone^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc ^[5]	complete
	GO:0019538	protein metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010603	P	Seeded from EcoCyc ^[5]	complete
	GO:0017111	nucleoside-triphosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F	Seeded from EcoCyc ^[5]	complete
	GO:0015031	protein transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004487	P	Seeded from EcoCyc ^[5]	complete
	GO:0016887	ATPase activity	GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004487 InterPro:IPR010603	F	Seeded from EcoCyc ^[5]	complete
	GO:0000166	nucleotide binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003593 SP_KW:KW-0547	F	Seeded from EcoCyc ^[5]	complete
	GO:0005515	protein binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004487	F	Seeded from EcoCyc ^[5]	complete
	GO:0005524	ATP binding	GO_REF:0000002 GO_REF:0000004 GO_REF:0000020	IEA: Inferred from Electronic Annotation	InterPro:IPR004487 SP_KW:KW-0067 HAMAP:MF_00175	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0006457	protein folding	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00175	P	Seeded from EcoCyc ^[5]	complete
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P	Seeded from EcoCyc ^[5]	complete
	GO:0008270	zinc ion binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR010603 SP_KW:KW-0862	F	Seeded from EcoCyc ^[5]	complete
	GO:0046983	protein dimerization activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010603	F	Seeded from EcoCyc ^[5]	complete
	GO:0051082	unfolded protein binding	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00175	F	Seeded from EcoCyc ^[5]	complete
	GO:0009050	glycopeptide catabolic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0006508	proteolysis				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0005737	cytoplasm				C	Seeded from EcoCyc 11.1^[3].	required fields missing
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of ClpX ATP-dependent protease specificity component and chaperone	could be indirect
Protein	clpA		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	clpB		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	metK		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	mreB		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	pstB		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	tufA		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	hscB		PMID:15690043^[7]	Experiment(s):EBI-884518
Protein	ahpC		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	dnaK		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	grpE		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	rfbB		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	rplL		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	rpmC		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	rpmG		PMID:15690043^[7]	Experiment(s):EBI-891405
Protein	slyB		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	intD		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	hypB		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	rho		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	dnaK		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	inaA		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	yhbJ		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	yibL		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	ybhK		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	sdhA		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	nadE		PMID:16606699^[8]	Experiment(s):EBI-1136646
Protein	Subunits of ClpAXP	could be indirect
Protein	Subunits of ClpXP	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Source	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MTDKRKDGSG KLLYCSFCGK SQHEVRKLIA GPSVYICDEC VDLCNDIIRE EIKEVAPHRE RSALPTPHEI RNHLDDYVIG QEQAKKVLAV AVYNHYKRLR NGDTSNGVEL GKSNILLIGP TGSGKTLLAE TLARLLDVPF TMADATTLTE AGYVGEDVEN IIQKLLQKCD YDVQKAQRGI VYIDEIDKIS RKSDNPSITR DVSGEGVQQA LLKLIEGTVA AVPPQGGRKH PQQEFLQVDT SKILFICGGA FAGLDKVISH RVETGSGIGF GATVKAKSDK ASEGELLAQV EPEDLIKFGL IPEFIGRLPV VATLNELSEE ALIQILKEPK NALTKQYQAL FNLEGVDLEF RDEALDAIAK KAMARKTGAR GLRSIVEAAL LDTMYDLPSM EDVEKVVIDE SVIDGQSKPL LIYGKPEAQQ ASGE
Length	424
Mol. Wt	46.356 kDa
pI	5.1 (calculated)
Extinction coefficient	16,390 - 17,265 (calc based on 11 Y, W, and 7 C residues)
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Domains/Motifs/Modification Sites

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Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P0A6H1
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Structure
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Structures

Representative Escherichia coli K-12 structure:
3HTE|A
1-363 of 424 residues (E-value: 1e-187) (Percent Identity: 99.72)
View the PDB Table for clpX

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:EG10159-MONOMER
SwissModel (EcoliWiki Page)	SwissModel:P0A6H1
UniProt (EcoliWiki Page)	UniProt:P0A6H1
PFAM (EcoliWiki Page)	PFAM:PF06689
RefSeq (EcoliWiki Page)	RefSeq:NP_414972
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page

clpX:Gene Product(s)

From EcoliWiki

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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