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cydA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CydA

Synonyms

cytochrome d terminal oxidase, subunit I[1], B0733[2][1], CydA[2][1]

Product description

cytochrome bd-I terminal oxidase subunit I[2][3];

Component of cytochrome bd-I terminal oxidase[2][3]

Cytochrome d (bd-I) terminal oxidase subunit I; upregulated in biofilms and microaerobic conditions; aerobically repressed by H-NS; anaerobically repressed by Fnr[4]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0005506

iron ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0408

F

Seeded from EcoCyc [5]

complete

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc [5]

complete

GO:0016491

oxidoreductase activity

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002585
SP_KW:KW-0560

F

Seeded from EcoCyc [5]

complete

GO:0031224

intrinsic to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc [5]

complete

GO:0009055

electron carrier activity

PMID:16299377[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0016679

oxidoreductase activity, acting on diphenols and related substances as donors

PMID:6321507[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [5]

complete

GO:0017004

cytochrome complex assembly

PMID:2856143[9]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc [5]

complete

GO:0020037

heme binding

PMID:8516338[10]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [5]

complete

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [5]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002585
SP_KW:KW-0472

C

Seeded from EcoCyc [5]

complete

GO:0022900

electron transport chain

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0249

P

Seeded from EcoCyc [5]

complete

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc [5]

complete

GO:0055114

oxidation reduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc [5]

complete

GO:0009054

electron acceptor activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of [[:Category:Complex:cytochrome bd-I terminal oxidase|cytochrome bd-I terminal oxidase]]

could be indirect


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

plasma membrane

C-terminus localized in the cytoplasm with 9 predicted transmembrane domains

Daley et al. (2005) [11]


Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MMLDIVELSR LQFALTAMYH FLFVPLTLGM AFLLAIMETV YVLSGKQIYK DMTKFWGKLF
GINFALGVAT GLTMEFQFGT NWSYYSHYVG DIFGAPLAIE GLMAFFLEST FVGLFFFGWD
RLGKVQHMCV TWLVALGSNL SALWILVANG WMQNPIASDF NFETMRMEMV SFSELVLNPV
AQVKFVHTVA SGYVTGAMFI LGISAWYMLK GRDFAFAKRS FAIAASFGMA AVLSVIVLGD
ESGYEMGDVQ KTKLAAIEAE WETQPAPAAF TLFGIPDQEE ETNKFAIQIP YALGIIATRS
VDTPVIGLKE LMVQHEERIR NGMKAYSLLE QLRSGSTDQA VRDQFNSMKK DLGYGLLLKR
YTPNVADATE AQIQQATKDS IPRVAPLYFA FRIMVACGFL LLAIIALSFW SVIRNRIGEK
KWLLRAALYG IPLPWIAVEA GWFVAEYGRQ PWAIGEVLPT AVANSSLTAG DLIFSMVLIC
GLYTLFLVAE LFLMFKFARL GPSSLKTGRY HFEQSSTTTQ PAR
Length

523

Mol. Wt

58.338 kDa

pI

6.8 (calculated)

Extinction coefficient

98,320 - 98,695 (calc based on 18 Y, 13 W, and 3 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences


tmhmm.php?gene=cydA&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:CYDA-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0ABJ9

PFAM (EcoliWiki Page)

PFAM:PF01654

RefSeq (EcoliWiki Page)

RefSeq:NP_415261

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:CYDA-MONOMER


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. Matsumoto Y et al. (2006) Mass spectrometric analysis of the ubiquinol-binding site in cytochrome bd from Escherichia coli. J Biol Chem 281: 1905-12 PubMed EcoliWiki page
  7. EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  8. Kita K et al. (1984) Terminal oxidases of Escherichia coli aerobic respiratory chain. II. Purification and properties of cytochrome b558-d complex from cells grown with limited oxygen and evidence of branched electron-carrying systems. J Biol Chem 259: 3375-81 PubMed EcoliWiki page
  9. Miller MJ & Gennis RB (1986) Purification and reconstitution of the cytochrome d terminal oxidase complex from Escherichia coli. Methods Enzymol 126: 87-94 PubMed EcoliWiki page
  10. Hill JJ et al. (1993) Spectroscopic evidence for a heme-heme binuclear center in the cytochrome bd ubiquinol oxidase from Escherichia coli. Proc Natl Acad Sci U S A 90: 5863-7 PubMed EcoliWiki page
  11. Daley DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308: 1321-3 PubMed EcoliWiki page

Categories

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[[Category:Complex:cytochrome bd-I terminal oxidase]]
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