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der:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Der

Synonyms

predicted GTP-binding protein[1], B2511[2][1], Der[2][1], YfgK[2][1], EngA[2][1]

Product description

50S ribosomal subunit stability factor[2][3]

Multicopy suppressor of ftsJ; depleted cells form filaments with defective chromosome segregation; GTPase[4]

EC number (for enzymes)


Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002917

C

Seeded from EcoCyc [5]

complete

GO:0005525

GTP binding

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR002917
InterPro:IPR005225
InterPro:IPR005289
InterPro:IPR006073
SP_KW:KW-0342
HAMAP:MF_00195

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc [5]

complete

GO:0009282

cytosolic large ribosomal subunit (sensu Bacteria)

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0000027

ribosomal large subunit assembly and maintenance

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0042273

ribosomal large subunit biogenesis and assembly

P

Seeded from EcoCyc 11.1[3].

required fields missing

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

ynbC

PMID:15690043[7]

Experiment(s):EBI-878632

Protein

rplB

PMID:15690043[7]

Experiment(s):EBI-878632

Protein

rplD

PMID:15690043[7]

Experiment(s):EBI-878632

Protein

rplN

PMID:15690043[7]

Experiment(s):EBI-878632

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-878632

Protein

rpsC

PMID:15690043[7]

Experiment(s):EBI-878632

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MRCLMIYKNE ALNMVPVVAL VGRPNVGKST LFNRLTRTRD ALVADFPGLT RDRKYGRAEI
EGREFICIDT GGIDGTEDGV ETRMAEQSLL AIEEADVVLF MVDARAGLMP ADEAIAKHLR
SREKPTFLVA NKTDGLDPDQ AVVDFYSLGL GEIYPIAASH GRGVLSLLEH VLLPWMEDLA
PQEEVDEDAE YWAQFEAEEN GEEEEEDDFD PQSLPIKLAI VGRPNVGKST LTNRILGEER
VVVYDMPGTT RDSIYIPMER DGREYVLIDT AGVRKRGKIT DAVEKFSVIK TLQAIEDANV
VMLVIDAREG ISDQDLSLLG FILNSGRSLV IVVNKWDGLS QEVKEQVKET LDFRLGFIDF
ARVHFISALH GSGVGNLFES VREAYDSSTR RVGTSMLTRI MTMAVEDHQP PLVRGRRVKL
KYAHAGGYNP PIVVIHGNQV KDLPDSYKRY LMNYFRKSLD VMGSPIRIQF KEGENPYANK
RNTLTPTQMR KRKRLMKHIK KNK
Length

503

Mol. Wt

56.617 kDa

pI

5.8 (calculated)

Extinction coefficient

38,850 - 39,100 (calc based on 15 Y, 3 W, and 2 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences


Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G7319-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A6P5

PFAM (EcoliWiki Page)

PFAM:PF01926

RefSeq (EcoliWiki Page)

RefSeq:NP_417006


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page

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