dipZ:Quickview

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Standard Name	dsbD
Gene Synonym(s)	dipZ, ECK4130, b4136, JW5734, cutA2, cycZ, htrI, dsbD[1][2]
Product Desc.	fused thiol:disulfide interchange protein[3]'/>: membrane electron transporter[4]'/>: activator of DsbC[1]
Product Synonyms(s)	B4136[2][1], HtrI[2][1], CycZ[2][1], DipZ
Function from GO	Molecular Function GO:0016491 oxidoreductase activity (IDA) Cellular Component GO:0005887 integral to plasma membrane (IDA) Biological Process GO:0017004 cytochrome complex assembly (IMP) GO:0006950 response to stress (IMP) GO:0042493 response to drug (IMP) GO:0071502 cellular response to temperature stimulus (IMP) GO:0055114 oxidation reduction (IDA)
Knock-Out Phenotype	copper sensitivity PMID:8917542[4] PMID:16087673[5]: temperature sensitivity PMID:7628442[3]
Regulation/Expression
Regulation/Activity	The bacterial membrane protein DsbD transfers electrons across the cytoplasmic membrane to reduce protein disulfide bonds in extracytoplasmic proteins. Its substrates include protein disulfide isomerases and a protein involved in cytochrome c assembly. It has three domains, each containing two redox-active cysteines. Electrons are transferred between them through thiol-disulfide exchange reactions.
Quick Links	DNA display    Protein display    Pubmed(dipZ)    Textpresso(dipZ)
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Notes

References

1. ↑ ^{1.0 1.1 1.2 1.3 1.4} Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
2. ↑ ^{2.0 2.1 2.2 2.3} EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
3. ↑ ^{3.0 3.1} Missiakas D et al. (1995) Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. EMBO J 14: 3415-24 PubMed EcoliWiki page
4. ↑ ^{4.0 4.1} Rietsch A et al. (1996) An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc Natl Acad Sci U S A 93: 13048-53 PubMed EcoliWiki page
5. ↑ Hiniker A et al. (2005) Copper stress causes an in vivo requirement for the Escherichia coli disulfide isomerase DsbC. J Biol Chem 280: 33785-91 PubMed EcoliWiki page