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dipZ:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

DsbD

Synonyms

B4136[1][2], HtrI[1][2], CycZ[1][2], DipZ

Product description

fused thiol:disulfide interchange protein[3]: membrane electron transporter[4]: activator of DsbC[2]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki. See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0047134

protein-disulfide reductase activity

GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

EC:1.8.1.8
HAMAP:MF_00399

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0045454

cell redox homeostasis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006662

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0017004

cytochrome complex assembly

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR003834
SP_KW:KW-0201
HAMAP:MF_00399

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003834
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0009055

electron carrier activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00399

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0006790

sulfur metabolic process

P

Seeded from EcoCyc 11.1[6].

required fields missing

GO:0005887

integral to plasma membrane

PMID:19258316[7]

IDA: Inferred from Direct Assay

C

complete

GO:0017004

cytochrome complex assembly

PMID:7957865[8]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions

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Partner TypePartnerNotesReferencesEvidence
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Notes

Localization

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CompartmentDescriptionEvidenceSourceNotes

Inner membrane

N- and C-terminal two soluble domains localized to the periplasm with central 8 transmembrane segment domains

PMID:10712691[9] PMID:10545108[10]

plasma membrane

From EcoCyc[6]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MAQRIFTLIL LLCSTSVFAG LFDAPGRSQF VPADQAFAFD FQQNQHDLNL TWQIKDGYYL
YRKQIRITPE HAKIADVQLP QGVWHEDEFY GKSEIYRDRL TLPVTINQAS AGATLTVTYQ
GCADAGFCYP PETKTVPLSE VVANNAAPQP VSVPQQEQPT AQLPFSALWA LLIGIGIAFT
PCVLPMYPLI SGIVLGGKQR LSTARALLLT FIYVQGMALT YTALGLVVAA AGLQFQAALQ
HPYVLIGLAI VFTLLAMSMF GLFTLQLPSS LQTRLTLMSN RQQGGSPGGV FVMGAIAGLI
CSPCTTAPLS AILLYIAQSG NMWLGGGTLY LYALGMGLPL MLITVFGNRL LPKSGPWMEQ
VKTAFGFVIL ALPVFLLERV IGDVWGLRLW SALGVAFFGW AFITSLQAKR GWMRIVQIIL
LAAALVSVRP LQDWAFGATH TAQTQTHLNF TQIKTVDELN QALVEAKGKP VMLDLYADWC
VACKEFEKYT FSDPQVQKAL ADTVLLQANV TANDAQDVAL LKHLNVLGLP TILFFDGQGQ
EHPQARVTGF MDAETFSAHL RDRQP
Length

565

Mol. Wt

61.796 kDa

pI

7.1 (calculated)

Extinction coefficient

84,340 - 85,340 (calc based on 16 Y, 11 W, and 8 C residues)

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Domains/Motifs/Modification Sites

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TypeResiduesDescriptionNotesReferences

motif

1-19

UniProt Manual:Signal Peptides

UniProt:P36655


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rectanglemotifs

tmhmm.php?gene=dsbD&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
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Structures
  • Representative Escherichia coli structure:
    1JPE|A
    19-151 of 565 residues (E-value: 4e-71) (Percent Identity: 99.25)
  • Representative homolog:
    1VRS|A (Escherichia coli str. K-12 substr. W3110)
    1-143 of 565 residues (E-value: 7e-76) (Percent Identity: 99.30)
  • View the PDB Table for dipZ
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:DSBD-MONOMER

UniProt (EcoliWiki Page)

UniProt:P36655

PFAM (EcoliWiki Page)

PFAM:PF02683

RefSeq (EcoliWiki Page)

RefSeq:NP_418559


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Notes

Links

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References

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  1. ↑ 1.0 1.1 1.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  3. ↑ Missiakas D et al. (1995) Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. EMBO J 14: 3415-24 PubMed EcoliWiki page
  4. ↑ Rietsch A et al. (1996) An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc Natl Acad Sci U S A 93: 13048-53 PubMed EcoliWiki page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Cho SH & Beckwith J (2009) Two snapshots of electron transport across the membrane: insights into the structure and function of DsbD. J Biol Chem 284: 11416-24 PubMed EcoliWiki page
  8. ↑ Sambongi Y & Ferguson SJ (1994) Specific thiol compounds complement deficiency in c-type cytochrome biogenesis in Escherichia coli carrying a mutation in a membrane-bound disulphide isomerase-like protein. FEBS Lett 353: 235-8 PubMed EcoliWiki page
  9. ↑ Chung J et al. (2000) Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm. Mol Microbiol 35: 1099-109 PubMed EcoliWiki page
  10. ↑ Stewart EJ et al. (1999) Six conserved cysteines of the membrane protein DsbD are required for the transfer of electrons from the cytoplasm to the periplasm of Escherichia coli. EMBO J 18: 5963-71 PubMed EcoliWiki page

Categories

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