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dnaE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DnaE

Synonyms

DNA polymerase III alpha subunit[1], B0184[2][1], SdgC[2][1], PolC[2][1], DnaE[2][1]

Product description

DNA polymerase III, α subunit[2][3];

Component of DNA polymerase III, core enzyme[3]; DNA polymerase III, holoenzyme[3]

DNA polymerase III, alpha subunit; suppressor of dnaG-Ts[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0016779

nucleotidyltransferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0548

F

Seeded from EcoCyc [5]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [5]

complete

GO:0008408

3'-5' exonuclease activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004805
InterPro:IPR011708

F

Seeded from EcoCyc [5]

complete

GO:0006260

DNA replication

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003141
InterPro:IPR004805
InterPro:IPR011708
SP_KW:KW-0235

P

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004805
InterPro:IPR011708
SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0003887

DNA-directed DNA polymerase activity

GO_REF:0000002
GO_REF:0000003
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003141
EC:2.7.7.7
SP_KW:KW-0239

F

Seeded from EcoCyc [5]

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003141

F

Seeded from EcoCyc [5]

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004365

F

Seeded from EcoCyc [5]

complete

GO:0005515

protein binding

PMID:16606699[7]

IPI: Inferred from Physical Interaction

UniProtKB:P30855

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:16606699[7]

IPI: Inferred from Physical Interaction

UniProtKB:P77374

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:17109382[8]

IPI: Inferred from Physical Interaction

UniProtKB:P03007

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0003824

catalytic activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004013
InterPro:IPR016195

F

Seeded from EcoCyc [5]

complete

GO:0006261

DNA-dependent DNA replication

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of DNA polymerase III, core enzyme

could be indirect

Protein

ssb

PMID:15690043[9]

Experiment(s):EBI-883487

Protein

aceE

PMID:15690043[9]

Experiment(s):EBI-883487

Protein

dnaX

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-890781

Protein

holA

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-890781

Protein

holB

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-880223

Protein

holC

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-880166, EBI-885330, EBI-890781

Protein

holD

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-880133, EBI-890781

Protein

rpsB

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-890781

Protein

tufA

PMID:15690043[9]

Experiment(s):EBI-883487, EBI-890781

Protein

pta

PMID:16606699[7]

Experiment(s):EBI-1135853

Protein

helD

PMID:16606699[7]

Experiment(s):EBI-1135853

Protein

asnB

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

dnaK

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

hrpB

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

lpdA

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

nikD

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rhsD

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rplA

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rplC

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rplD

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rplL

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rplM

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rplU

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rpsA

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

rpsP

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

tpiA

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

ybdL

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

bcsA

PMID:15690043[9]

Experiment(s):EBI-890781

Protein

Subunits of DNA polymerase III, holoenzyme

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSEPRFVHLR VHSDYSMIDG LAKTAPLVKK AAALGMPALA ITDFTNLCGL VKFYGAGHGA
GIKPIVGADF NVQCDLLGDE LTHLTVLAAN NTGYQNLTLL ISKAYQRGYG AAGPIIDRDW
LIELNEGLIL LSGGRMGDVG RSLLRGNSAL VDECVAFYEE HFPDRYFLEL IRTGRPDEES
YLHAAVELAE ARGLPVVATN DVRFIDSSDF DAHEIRVAIH DGFTLDDPKR PRNYSPQQYM
RSEEEMCELF ADIPEALANT VEIAKRCNVT VRLGEYFLPQ FPTGDMSTED YLVKRAKEGL
EERLAFLFPD EEERLKRRPE YDERLETELQ VINQMGFPGY FLIVMEFIQW SKDNGVPVGP
GRGSGAGSLV AYALKITDLD PLEFDLLFER FLNPERVSMP DFDVDFCMEK RDQVIEHVAD
MYGRDAVSQI ITFGTMAAKA VIRDVGRVLG HPYGFVDRIS KLIPPDPGMT LAKAFEAEPQ
LPEIYEADEE VKALIDMARK LEGVTRNAGK HAGGVVIAPT KITDFAPLYC DEEGKHPVTQ
FDKSDVEYAG LVKFDFLGLR TLTIINWALE MINKRRAKNG EPPLDIAAIP LDDKKSFDML
QRSETTAVFQ LESRGMKDLI KRLQPDCFED MIALVALFRP GPLQSGMVDN FIDRKHGREE
ISYPDVQWQH ESLKPVLEPT YGIILYQEQV MQIAQVLSGY TLGGADMLRR AMGKKKPEEM
AKQRSVFAEG AEKNGINAEL AMKIFDLVEK FAGYGFNKSH SAAYALVSYQ TLWLKAHYPA
EFMAAVMTAD MDNTEKVVGL VDECWRMGLK ILPPDINSGL YHFHVNDDGE IVYGIGAIKG
VGEGPIEAII EARNKGGYFR ELFDLCARTD TKKLNRRVLE KLIMSGAFDR LGPHRAALMN
SLGDALKAAD QHAKAEAIGQ ADMFGVLAEE PEQIEQSYAS CQPWPEQVVL DGERETLGLY
LTGHPINQYL KEIERYVGGV RLKDMHPTER GKVITAAGLV VAARVMVTKR GNRIGICTLD
DRSGRLEVML FTDALDKYQQ LLEKDRILIV SGQVSFDDFS GGLKMTAREV MDIDEAREKY
ARGLAISLTD RQIDDQLLNR LRQSLEPHRS GTIPVHLYYQ RADARARLRF GATWRVSPSD
RLLNDLRGLI GSEQVELEFD
Length

1,160

Mol. Wt

129.908 kDa

pI

5.1 (calculated)

Extinction coefficient

102,110 - 103,610 (calc based on 39 Y, 8 W, and 12 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10238-MONOMER

UniProt (EcoliWiki Page)

UniProt:P10443

PFAM (EcoliWiki Page)

PFAM:PF02231

RefSeq (EcoliWiki Page)

RefSeq:NP_414726


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 6.3 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 7.2 7.3 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
  8. ↑ Oishi Y et al. (2006) Escherichia coli proteome chips for detecting protein-protein interactions. Proteomics 6: 6433-6 PubMed EcoliWiki page
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 9.18 9.19 9.20 9.21 9.22 9.23 9.24 9.25 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page

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