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envC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

EnvC

Synonyms

protease with a role in cell division[1], B3613[2][1], EnvC[2][1], YibP[2][1] , ECK3603, JW5646, slm11, yibP, b3613

Product description

EnvC murein hydrolase[2][3]

Periplasmic murein hydrolase septal ring factor; sensitivity to crystal violet; filamentous[4]

EC number (for enzymes)


Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0042493

response to drug

PMID:8407802[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0016787

hydrolase activity

PMID:15165230[6]

IDA: Inferred from Direct Assay

F

murein hydrolase activity

complete

GO:0042597

periplasmic space

PMID:15165230[6]

IMP: Inferred from Mutant Phenotype

C

complete

GO:0000920

cytokinetic cell separation

PMID:19525345[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000920

cytokinetic cell separation

PMID:19525345[7]

IGI: Inferred from Genetic Interaction

EcoliWiki:NlpD

P

complete

GO:0004222

metalloendopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002886

F

Seeded from EcoCyc (v14.0)

complete

GO:0006508

proteolysis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002886

P

Seeded from EcoCyc (v14.0)

complete

GO:0032155

cell division site part

PMID:19525345[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0001896

autolysis

PMID:19525345[7]

IGI: Inferred from Genetic Interaction

EcoliWiki:nlpD|EcoliWiki:yebA|EcoliWiki:ygeR

P

ampicillin- induced autolysis

complete

GO:0032155

cell division site part

PMID:19525345[7]

IDA: Inferred from Direct Assay

C

shows midcell localization in both short unconstricted cells and longer cells with a constriction

complete

GO:0000920

cytokinetic cell separation

PMID:19525345[7]

IGI: Inferred from Genetic Interaction

EcoliWiki:nlpD|EcoliWiki:yebA|EcoliWiki:ygeR

P

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Inner Membrane

PMID:8472900

EchoLocation:envC

periplasm


Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MRGKAINTMT RAVKPRRFAI RPIIYASVLS AGVLLCAFSA HADERDQLKS IQADIAAKER
AVRQKQQQRA SLLAQLKKQE EAISEATRKL RETQNTLNQL NKQIDEMNAS IAKLEQQKAA
QERSLAAQLD AAFRQGEHTG IQLILSGEES QRGQRLQAYF GYLNQARQET IAQLKQTREE
VAMQRAELEE KQSEQQTLLY EQRAQQAKLT QALNERKKTL AGLESSIQQG QQQLSELRAN
ESRLRNSIAR AEAAAKARAE REAREAQAVR DRQKEATRKG TTYKPTESEK SLMSRTGGLG
APRGQAFWPV RGPTLHRYGE QLQGELRWKG MVIGASEGTE VKAIADGRVI LADWLQGYGL
VVVVEHGKGD MSLYGYNQSA LVSVGSQVRA GQPIALVGSS GGQGRPSLYF EIRRQGQAVN
PQPWLGR
Length

427

Mol. Wt

47.466 kDa

pI

10.4 (calculated)

Extinction coefficient

36,900 - 37,025 (calc based on 10 Y, 4 W, and 1 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

319..413

PF01551 Peptidase family M23

PMID:19920124[8]


rectanglemotifs

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

No results found for a best structure.

Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:162135913

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948129

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011820

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P37690

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12297

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12297

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948129

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002178

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2205

Escherichia coli str. K-12 substr. MG1655

Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Ma, D et al. (1993) Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175 6299-313 PubMed EcoliWiki page
  6. 6.0 6.1 Bernhardt, TG & de Boer, PA (2004) Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity. Mol. Microbiol. 52 1255-69 PubMed EcoliWiki page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Uehara, T et al. (2009) LytM-domain factors are required for daughter cell separation and rapid ampicillin-induced lysis in Escherichia coli. J. Bacteriol. 191 5094-107 PubMed EcoliWiki page
  8. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed EcoliWiki page

Categories

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