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fabZ:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabZ

Synonyms

(3R)-hydroxymyristol acyl carrier protein dehydratase[1], B0180[2][1], YaeA[2][1], SefA[2][1], FabZ[2][1]

Product description

FabZ[2][3];

Component of FABZ-CPLX[2]

3R-hydroxymyristoyl acyl carrier protein (ACP) dehydratase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0016836

hydro-lyase activity

GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR010084
HAMAP:MF_00406

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0016829

lyase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc [6]

complete

GO:0009245

lipid A biosynthetic process

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441
HAMAP:MF_00406

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0008610

lipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc [6]

complete

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010084

P

Seeded from EcoCyc [6]

complete

GO:0005737

cytoplasm

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR010084
SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0006654

phosphatidic acid biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of FABZ-CPLX

could be indirect

Protein

clpA

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

ffh

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

glnS

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

lon

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplA

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplB

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplC

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplD

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplE

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplF

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplI

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplJ

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplM

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplS

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rpsA

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rpsC

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rpsD

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rpsE

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

rpsG

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

tufA

PMID:15690043[7]

Experiment(s):EBI-887148

Protein

gfcD

PMID:16606699[8]

Experiment(s):EBI-1135815

Protein

yjdA

PMID:16606699[8]

Experiment(s):EBI-1135815

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Cytoplasm

PMID:8354462[9], PMID:7806516[10], PMID:8805534[11], PMID:8910376[12]

EchoLocation:fabZ


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF FQGHFPGKPI
FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR FKRPVVPGDQ MIMEVTFEKT
RRGLTRFKGV ALVDGKVVCE ATMMCARSRE A
Length

151

Mol. Wt

17.032 kDa

pI

7.2 (calculated)

Extinction coefficient

2,980 - 3,230 (calc based on 2 Y, W, and 2 C residues)

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Domains/Motifs/Modification Sites

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TypeResiduesDescriptionNotesReferences
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:FABZ-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P0A6Q6

UniProt (EcoliWiki Page)

UniProt:P0A6Q6

PFAM (EcoliWiki Page)

PFAM:PF03061

RefSeq (EcoliWiki Page)

RefSeq:NP_414722


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 6.2 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page
  8. ↑ 8.0 8.1 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
  9. ↑ Foster SJ (1993) Purification and characterization of an 'actomyosin' complex from Escherichia coli W3110. FEMS Microbiol Lett 110: 295-8 PubMed EcoliWiki page
  10. ↑ Mohan S et al. (1994) An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. J Biol Chem 269: 32896-903 PubMed EcoliWiki page
  11. ↑ Leesong M et al. (1996) Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Structure 4: 253-64 PubMed EcoliWiki page
  12. ↑ Heath RJ & Rock CO (1996) Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. J Biol Chem 271: 27795-801 PubMed EcoliWiki page

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