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fabZ:On One Page

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Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

fabZ

Gene Synonym(s)

ECK0179, b0180, JW0175, sefA, yaeA, sabA, sfhC, sfhC21, sabA1, G465[1][2]

Product Desc.

FabZ[2][3];

Component of FABZ-CPLX[2]

3R-hydroxymyristoyl acyl carrier protein (ACP) dehydratase[4]

Product Synonyms(s)

(3R)-hydroxymyristol acyl carrier protein dehydratase[1], B0180[2][1], YaeA[2][1], SefA[2][1], FabZ[2][1]

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yaeT-hlpA-lpxD-fabZ-lpxAB-rnhB-dnaE[2], ecfK-skp-lpxD-fabZ-lpxAB-rnhB-dnaE, hlpA-lpxD-fabZ-lpxA[2], fabZ[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(fabZ)    Textpresso(fabZ)

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Notes

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Binds TrxA (Kumar, 2004).[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

fabZ

Mnemonic

Fatty acid biosynthesis

Synonyms

ECK0179, b0180, JW0175, sefA, yaeA, sabA, sfhC, sfhC21, sabA1, G465[1][2]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

4.36 minutes 

MG1655: 202101..202556
gbrowse_img.php?coord=202101..202556&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 204943..205398
gbrowse_img.php?coord=204943..205398&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 202101..202556
gbrowse_img.php?coord=202101..202556&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 176205..176660
gbrowse_img.php?coord=176205..176660&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 202100..202555
gbrowse_img.php?coord=202100..202555&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

sfhC21

Other

PMID:10048027

Suppressor of ftsH lethality

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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW0175

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCACTACTAACACTCATACTCT

Primer 2:CCGGCCTCCCGGCTACGAGCACA

zad-220::Tn10

Linked marker

CAG12025 = CGSC7326[5]

est. P1 cotransduction: 8% [6]

yafC502::Tn10

Linked marker

CAG18436 = CGSC7328[5]

est. P1 cotransduction: 31% [6]
Synonyms:zae-502::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11284

EchoBASE (EcoliWiki Page)

EchoBASE:EB1261

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0180

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C0217

EcoGene (EcoliWiki Page)

EcoGene:EG11284

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:FABZ

CGSC (EcoliWiki Page)

CGSC:30597

ASAP (EcoliWikiPage)

ASAP:ABE-0000613


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabZ

Synonyms

(3R)-hydroxymyristol acyl carrier protein dehydratase[1], B0180[2][1], YaeA[2][1], SefA[2][1], FabZ[2][1]

Product description

FabZ[2][3];

Component of FABZ-CPLX[2]

3R-hydroxymyristoyl acyl carrier protein (ACP) dehydratase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0016836

hydro-lyase activity

GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR010084
HAMAP:MF_00406

F

Seeded from EcoCyc 12.5 [7]

complete

GO:0016829

lyase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc [8]

complete

GO:0009245

lipid A biosynthetic process

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441
HAMAP:MF_00406

P

Seeded from EcoCyc 12.5 [7]

complete

GO:0008610

lipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc [8]

complete

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010084

P

Seeded from EcoCyc [8]

complete

GO:0005737

cytoplasm

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR010084
SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [7]

complete

GO:0006654

phosphatidic acid biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of FABZ-CPLX

could be indirect

Protein

clpA

PMID:15690043

Experiment(s):EBI-887148

Protein

ffh

PMID:15690043

Experiment(s):EBI-887148

Protein

glnS

PMID:15690043

Experiment(s):EBI-887148

Protein

lon

PMID:15690043

Experiment(s):EBI-887148

Protein

rplA

PMID:15690043

Experiment(s):EBI-887148

Protein

rplB

PMID:15690043

Experiment(s):EBI-887148

Protein

rplC

PMID:15690043

Experiment(s):EBI-887148

Protein

rplD

PMID:15690043

Experiment(s):EBI-887148

Protein

rplE

PMID:15690043

Experiment(s):EBI-887148

Protein

rplF

PMID:15690043

Experiment(s):EBI-887148

Protein

rplI

PMID:15690043

Experiment(s):EBI-887148

Protein

rplJ

PMID:15690043

Experiment(s):EBI-887148

Protein

rplM

PMID:15690043

Experiment(s):EBI-887148

Protein

rplS

PMID:15690043

Experiment(s):EBI-887148

Protein

rplV

PMID:15690043

Experiment(s):EBI-887148

Protein

rpsA

PMID:15690043

Experiment(s):EBI-887148

Protein

rpsB

PMID:15690043

Experiment(s):EBI-887148

Protein

rpsC

PMID:15690043

Experiment(s):EBI-887148

Protein

rpsD

PMID:15690043

Experiment(s):EBI-887148

Protein

rpsE

PMID:15690043

Experiment(s):EBI-887148

Protein

rpsG

PMID:15690043

Experiment(s):EBI-887148

Protein

tufA

PMID:15690043

Experiment(s):EBI-887148

Protein

gfcD

PMID:16606699

Experiment(s):EBI-1135815

Protein

yjdA

PMID:16606699

Experiment(s):EBI-1135815

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Cytoplasm

PMID:8354462, PMID:7806516, PMID:8805534, PMID:8910376

EchoLocation:fabZ


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF FQGHFPGKPI
FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR FKRPVVPGDQ MIMEVTFEKT
RRGLTRFKGV ALVDGKVVCE ATMMCARSRE A
Length

151

Mol. Wt

17.032 kDa

pI

7.2 (calculated)

Extinction coefficient

2,980 - 3,230 (calc based on 2 Y, W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:FABZ-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P0A6Q6

UniProt (EcoliWiki Page)

UniProt:P0A6Q6

PFAM (EcoliWiki Page)

PFAM:PF03061

RefSeq (EcoliWiki Page)

RefSeq:NP_414722


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

yaeT-hlpA-lpxD-fabZ-lpxAB-rnhB-dnaE

hlpA-lpxD-fabZ-lpxA

fabZ

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=202081..202121&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b0180 (EcoliWiki Page)

NCBI GEO profiles for fabZ

microarray

GenExpDB:b0180 (EcoliWiki Page)

Summary of data for fabZ from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes

GFP Fusion

Intergenic region (201915..202180) fused to gfpmut2.

OpenBioSystems

GFP fusion described in Zaslaver, et al.
Plate:109-AZ05; Well:H2[9]

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Notes

Accessions Related to fabZ Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11284

EchoBASE (EcoliWiki Page)

EchoBASE:EB1261

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0180

EcoGene (EcoliWiki Page)

EcoGene:EG11284


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Notes

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Anopheles gambiae

  • ENSANGP00000001958 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000031280 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT2G22230 (score: 1.000; bootstrap: 100%)
  • AT5G10160 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Oryza gramene

  • Q6I5L0 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000022453 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

FABZ

From SHIGELLACYC

E. coli O157

FABZ

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF03061


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  8. ↑ 8.0 8.1 8.2 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  9. ↑ Zaslaver A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat Methods 3: 623-8 PubMed EcoliWiki page

Categories

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