fhuA:Gene Product(s) - EcoliWiki
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fhuA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

FhuA product

Synonyms

ferrichrome outer membrane transporter product[1], B0150 product[2][1], TonA product[2][1], FhuA product[2][1]

Product description

FhuA outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80[2][3];

Component of ; Outer Membrane Ferrichrome Transport System[3]; ferrichrome uptake system[3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0046718

entry of virus into host cell

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0580

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0019867

outer membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0557

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR012910
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0015891

siderophore transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010105

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0015343

siderophore-iron transmembrane transporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010105

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0009597

detection of virus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0580

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0006826

iron ion transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0410

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0006811

ion transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0406

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR012910
SP_KW:KW-0813

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0005506

iron ion binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR010105
SP_KW:KW-0408

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0005215

transporter activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR012910

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0004872

receptor activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR010105
InterPro:IPR012910
SP_KW:KW-0675

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0009279

cell outer membrane

PMID:4580999[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc 11.1[3].

complete

GO:0046790

virion binding

PMID:4580999[5]

IMP: Inferred from Mutant Phenotype

F

Receptor for phages T1, T5 & phi80.

complete

GO:0015643

toxin binding

PMID:4584483[6]

IMP: Inferred from Mutant Phenotype

F

Receptor for colicin M.

complete

GO:0046790

virion binding

PMID:4584483[6]

IMP: Inferred from Mutant Phenotype

F

Receptor for phage T5.

complete

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Interactions

Partner TypePartnerNotesReferences

Protein

Subunits of Outer Membrane Ferrichrome Transport System

could be indirect

Protein

Subunits of ferrichrome uptake system

could be indirect


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Notes

Localization

CompartmentDescriptionEvidenceNotes

outer membrane

From EcoCyc[3]

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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc

MARSKTAQPK HSLRKIAVVV ATAVSGMSVY AQAAVEPKED TITVTAAPAP QESAWGPAAT
IAARQSATGT KTDTPIQKVP QSISVVTAEE MALHQPKSVK EALSYTPGVS VGTRGASNTY
DHLIIRGFAA EGQSQNNYLN GLKLQGNFYN DAVIDPYMLE RAEIMRGPVS VLYGKSSPGG
LLNMVSKRPT TEPLKEVQFK AGTDSLFQTG FDFSDSLDDD GVYSYRLTGL ARSANAQQKG
SEEQRYAIAP AFTWRPDDKT NFTFLSYFQN EPETGYYGWL PKEGTVEPLP NGKRLPTDFN
EGAKNNTYSR NEKMVGYSFD HEFNDTFTVR QNLRFAENKT SQNSVYGYGV CSDPANAYSK
QCAALAPADK GHYLARKYVV DDEKLQNFSV DTQLQSKFAT GDIDHTLLTG VDFMRMRNDI
NAWFGYDDSV PLLNLYNPVN TDFDFNAKDP ANSGPYRILN KQKQTGVYVQ DQAQWDKVLV
TLGGRYDWAD QESLNRVAGT TDKRDDKQFT WRGGVNYLFD NGVTPYFSYS ESFEPSSQVG
KDGNIFAPSK GKQYEVGVKY VPEDRPIVVT GAVYNLTKTN NLMADPEGSF FSVEGGEIRA
RGVEIEAKAA LSASVNVVGS YTYTDAEYTT DTTYKGNTPA QVPKHMASLW ADYTFFDGPL
SGLTLGTGGR YTGSSYGDPA NSFKVGSYTV VDALVRYDLA RVGMAGSNVA LHVNNLFDRE
YVASCFNTYG CFWGAERQVV ATATFRF
Mol. Wt

82.18 kDa (calc) [2]

pI
Extinction coefficient

112080 - 112580 (calc based on 42 Y, 9 W, and 4 C residues)

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Domains/Motifs/Modification Sites

TypeResiduesDescriptionNotes

motif

1-33

UniProt Manual:Signal Peptides

UniProt:P06971

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Structure

Structures
  • Representative Escherichia coli structure:
    1BY3|A
    1-714 of 747 residues (E-value: 0.) (Percent Identity: 99.72)
  • Representative homolog:
    1XKW|A (Pseudomonas aeruginosa)
    197-258 of 747 residues (E-value: 3.0e-06) (Percent Identity: 29.69)
  • View all other structures.
Models

View models at:

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Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10302-MONOMER

PDB (EcoliWiki Page)

PDB:1QKC

UniProt (EcoliWiki Page)

UniProt:P06971

PFAM (EcoliWiki Page)

PFAM:PF07715

RefSeq (EcoliWiki Page)

RefSeq:NP_414692

ModBase (EcoliWiki Page)

ModBase:P06971


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Notes

Links

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NameURLComments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. 5.0 5.1 Braun V & Wolff H (1973) Characterization of the receptor protein for phage T5 and colicin M in the outer membrane of E. coli B. FEBS Lett 34: 77-80 PubMed EcoliWiki page
  6. 6.0 6.1 Braun V et al. (1973) A common receptor protein for phage T5 and colicin M in the outer membrane of Escherichia coli B. Biochim Biophys Acta 323: 87-97 PubMed EcoliWiki page


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