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fhuA:Gene Product(s)
From EcoliWiki
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| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
FhuA |
|---|---|
| Synonyms |
ferrichrome outer membrane transporter[1], B0150[2][1], TonA[2][1], FhuA[2][1] |
| Product description |
FhuA outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80[2][3]; Component of Outer Membrane Ferrichrome Transport System[3]; ferrichrome uptake system[3] Outer membrane transporter for ferrichrome-iron; interacts with TonB; receptor for microcin J25, colicin M, and phages T1, T5, phi80; transports albomycin and rifamycin[4] |
| EC number (for enzymes) |
|
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0046718 |
entry of virus into host cell |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0019867 |
outer membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [5] |
complete | |||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [5] |
complete | |||
| GO:0015891 |
siderophore transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0015343 |
siderophore-iron transmembrane transporter activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0009597 |
detection of virus |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006826 |
iron ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0005506 |
iron ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0005215 |
transporter activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000531 |
F |
Seeded from EcoCyc [5] |
complete | ||
| GO:0009279 |
cell outer membrane |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc 11.1[3]. |
complete | |||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [5] |
complete | |||
| GO:0046790 |
virion binding |
IMP: Inferred from Mutant Phenotype |
F |
Receptor for phages T1, T5 & phi80. |
complete | |||
| GO:0015643 |
toxin binding |
IMP: Inferred from Mutant Phenotype |
F |
Receptor for colicin M. |
complete | |||
| GO:0046790 |
virion binding |
IMP: Inferred from Mutant Phenotype |
F |
Receptor for phage T5. |
complete | |||
| GO:0005506 |
iron ion binding |
IPI: Inferred from Physical Interaction |
F |
complete | ||||
| GO:0048037 |
cofactor binding |
IPI: Inferred from Physical Interaction |
F |
complete | ||||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of Outer Membrane Ferrichrome Transport System |
could be indirect | ||
|
Protein |
Subunits of ferrichrome uptake system |
could be indirect |
| |
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Source | Notes | |
|---|---|---|---|---|---|
|
outer membrane |
From EcoCyc[3] | ||||
|
Outer Membrane | PMID:3079747[10] |
| |||
| edit table |
Notes
Structure and Physical Properties
Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MARSKTAQPK HSLRKIAVVV ATAVSGMSVY AQAAVEPKED TITVTAAPAP QESAWGPAAT IAARQSATGT KTDTPIQKVP QSISVVTAEE MALHQPKSVK EALSYTPGVS VGTRGASNTY DHLIIRGFAA EGQSQNNYLN GLKLQGNFYN DAVIDPYMLE RAEIMRGPVS VLYGKSSPGG LLNMVSKRPT TEPLKEVQFK AGTDSLFQTG FDFSDSLDDD GVYSYRLTGL ARSANAQQKG SEEQRYAIAP AFTWRPDDKT NFTFLSYFQN EPETGYYGWL PKEGTVEPLP NGKRLPTDFN EGAKNNTYSR NEKMVGYSFD HEFNDTFTVR QNLRFAENKT SQNSVYGYGV CSDPANAYSK QCAALAPADK GHYLARKYVV DDEKLQNFSV DTQLQSKFAT GDIDHTLLTG VDFMRMRNDI NAWFGYDDSV PLLNLYNPVN TDFDFNAKDP ANSGPYRILN KQKQTGVYVQ DQAQWDKVLV TLGGRYDWAD QESLNRVAGT TDKRDDKQFT WRGGVNYLFD NGVTPYFSYS ESFEPSSQVG KDGNIFAPSK GKQYEVGVKY VPEDRPIVVT GAVYNLTKTN NLMADPEGSF FSVEGGEIRA RGVEIEAKAA LSASVNVVGS YTYTDAEYTT DTTYKGNTPA QVPKHMASLW ADYTFFDGPL SGLTLGTGGR YTGSSYGDPA NSFKVGSYTV VDALVRYDLA RVGMAGSNVA LHVNNLFDRE YVASCFNTYG CFWGAERQVV ATATFRF |
|---|---|
| Length |
747 |
| Mol. Wt |
82.182 kDa |
| pI |
5.4 (calculated) |
| Extinction coefficient |
112,080 - 112,580 (calc based on 42 Y, 9 W, and 4 C residues) |
| edit table |
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
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Structure
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Structure figures
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| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 7.0 7.1 Braun V & Wolff H (1973) Characterization of the receptor protein for phage T5 and colicin M in the outer membrane of E. coli B. FEBS Lett 34: 77-80 PubMed EcoliWiki page
- ↑ 8.0 8.1 Braun V et al. (1973) A common receptor protein for phage T5 and colicin M in the outer membrane of Escherichia coli B. Biochim Biophys Acta 323: 87-97 PubMed EcoliWiki page
- ↑ 9.0 9.1 Faraldo-Gómez JD et al. (2003) Molecular dynamics simulations of the bacterial outer membrane protein FhuA: a comparative study of the ferrichrome-free and bound states. Biophys J 85: 1406-20 PubMed EcoliWiki page
- ↑ Coulton JW et al. (1986) Protein fusions of beta-galactosidase to the ferrichrome-iron receptor of Escherichia coli K-12. J Bacteriol 165: 181-92 PubMed EcoliWiki page

