EcoliHub logo

Try the new EcoliHub and let us know what you'd like to see.

fhuA:Gene Product(s)

From EcoliWiki

Jump to: navigation, search


Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FhuA

Synonyms

ferrichrome outer membrane transporter[1], B0150[2][1], TonA[2][1], FhuA[2][1]

Product description

FhuA outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80[2][3];

Component of Outer Membrane Ferrichrome Transport System[3]; ferrichrome uptake system[3]

Outer membrane transporter for ferrichrome-iron; interacts with TonB; receptor for microcin J25, colicin M, and phages T1, T5, phi80; transports albomycin and rifamycin[4]

EC number (for enzymes)


Notes

Function

[back to top]


Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0046718

entry of virus into host cell

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0580

P

Seeded from EcoCyc [5]

complete

GO:0019867

outer membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0557

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc [5]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR012910
SP_KW:KW-0472

C

Seeded from EcoCyc [5]

complete

GO:0015891

siderophore transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010105

P

Seeded from EcoCyc [5]

complete

GO:0015343

siderophore-iron transmembrane transporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010105

F

Seeded from EcoCyc [5]

complete

GO:0009597

detection of virus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0580

P

Seeded from EcoCyc [5]

complete

GO:0006826

iron ion transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0410

P

Seeded from EcoCyc [5]

complete

GO:0006811

ion transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0406

P

Seeded from EcoCyc [5]

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR012910
SP_KW:KW-0813

P

Seeded from EcoCyc [5]

complete

GO:0005506

iron ion binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR010105
SP_KW:KW-0408

F

Seeded from EcoCyc [5]

complete

GO:0005215

transporter activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR012910

F

Seeded from EcoCyc [5]

complete

GO:0004872

receptor activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000531
InterPro:IPR010105
InterPro:IPR012910
SP_KW:KW-0675

F

Seeded from EcoCyc [5]

complete

GO:0009279

cell outer membrane

PMID:4580999[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc 11.1[3].

complete

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc [5]

complete

GO:0046790

virion binding

PMID:4580999[7]

IMP: Inferred from Mutant Phenotype

F

Receptor for phages T1, T5 & phi80.

complete

GO:0015643

toxin binding

PMID:4584483[8]

IMP: Inferred from Mutant Phenotype

F

Receptor for colicin M.

complete

GO:0046790

virion binding

PMID:4584483[8]

IMP: Inferred from Mutant Phenotype

F

Receptor for phage T5.

complete

GO:0005506

iron ion binding

PMID:12944258[9]

IPI: Inferred from Physical Interaction

CHEBI:18248

F

complete

GO:0048037

cofactor binding

PMID:12944258[9]

IPI: Inferred from Physical Interaction

CHEBI:26672

F

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of Outer Membrane Ferrichrome Transport System

could be indirect

Protein

Subunits of ferrichrome uptake system

could be indirect


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

outer membrane

From EcoCyc[3]

Outer Membrane

PMID:3079747[10]

EchoLocation:fhuA


Notes

Structure and Physical Properties

[back to top]


Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MARSKTAQPK HSLRKIAVVV ATAVSGMSVY AQAAVEPKED TITVTAAPAP QESAWGPAAT
IAARQSATGT KTDTPIQKVP QSISVVTAEE MALHQPKSVK EALSYTPGVS VGTRGASNTY
DHLIIRGFAA EGQSQNNYLN GLKLQGNFYN DAVIDPYMLE RAEIMRGPVS VLYGKSSPGG
LLNMVSKRPT TEPLKEVQFK AGTDSLFQTG FDFSDSLDDD GVYSYRLTGL ARSANAQQKG
SEEQRYAIAP AFTWRPDDKT NFTFLSYFQN EPETGYYGWL PKEGTVEPLP NGKRLPTDFN
EGAKNNTYSR NEKMVGYSFD HEFNDTFTVR QNLRFAENKT SQNSVYGYGV CSDPANAYSK
QCAALAPADK GHYLARKYVV DDEKLQNFSV DTQLQSKFAT GDIDHTLLTG VDFMRMRNDI
NAWFGYDDSV PLLNLYNPVN TDFDFNAKDP ANSGPYRILN KQKQTGVYVQ DQAQWDKVLV
TLGGRYDWAD QESLNRVAGT TDKRDDKQFT WRGGVNYLFD NGVTPYFSYS ESFEPSSQVG
KDGNIFAPSK GKQYEVGVKY VPEDRPIVVT GAVYNLTKTN NLMADPEGSF FSVEGGEIRA
RGVEIEAKAA LSASVNVVGS YTYTDAEYTT DTTYKGNTPA QVPKHMASLW ADYTFFDGPL
SGLTLGTGGR YTGSSYGDPA NSFKVGSYTV VDALVRYDLA RVGMAGSNVA LHVNNLFDRE
YVASCFNTYG CFWGAERQVV ATATFRF
Length

747

Mol. Wt

82.182 kDa

pI

5.4 (calculated)

Extinction coefficient

112,080 - 112,580 (calc based on 42 Y, 9 W, and 4 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

motif

1-33

UniProt Manual:Signal Peptides

UniProt:P06971



rectanglerectanglemotifs

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10302-MONOMER

UniProt (EcoliWiki Page)

UniProt:P06971

PFAM (EcoliWiki Page)

PFAM:PF07715

RefSeq (EcoliWiki Page)

RefSeq:NP_414692


Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. 7.0 7.1 Braun V & Wolff H (1973) Characterization of the receptor protein for phage T5 and colicin M in the outer membrane of E. coli B. FEBS Lett 34: 77-80 PubMed EcoliWiki page
  8. 8.0 8.1 Braun V et al. (1973) A common receptor protein for phage T5 and colicin M in the outer membrane of Escherichia coli B. Biochim Biophys Acta 323: 87-97 PubMed EcoliWiki page
  9. 9.0 9.1 Faraldo-Gómez JD et al. (2003) Molecular dynamics simulations of the bacterial outer membrane protein FhuA: a comparative study of the ferrichrome-free and bound states. Biophys J 85: 1406-20 PubMed EcoliWiki page
  10. Coulton JW et al. (1986) Protein fusions of beta-galactosidase to the ferrichrome-iron receptor of Escherichia coli K-12. J Bacteriol 165: 181-92 PubMed EcoliWiki page

Categories

[back to top]

Personal tools
page contributors