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Quickview | Gene | Product(s) | Expression| Evolution | References |

Quickview

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See Help:Quickview for help with entering information in the Quickview table.

Standard Name

fmt

Gene Synonym(s)

ECK3274, b3288, JW3249, yhdD, ftm[1]

Product Desc.

10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase[2][3]

Methionyl-tRNA formyltransferase[4]

Product Synonyms(s)

10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase[1], B3288[2][1], Ftm[2][1], YhdD[2][1], Fmt[2][1]

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): def-fmt[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(fmt)    Textpresso(fmt)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

fmt

Mnemonic

fMet-tRNA formyltransferase

Synonyms

ECK3274, b3288, JW3249, yhdD, ftm[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

73.98 minutes 

MG1655: 3432236..3433183
gbrowse_img.php?coord=3432236..3433183&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 3362119..3363066
gbrowse_img.php?coord=3362119..3363066&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 4206202..4205255
gbrowse_img.php?coord=4205255..4206202&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 3529981..3530928
gbrowse_img.php?coord=3529981..3530928&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 3319393..3320340
gbrowse_img.php?coord=3319393..3320340&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW3249

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCTCAGAATCACTACGTATTAT

Primer 2:CCGACCAGACGGTTGCCCGGAAC

smg-3082::Tn10

Linked marker

CAG12071 = CGSC7444[5]

est. P1 cotransduction: 89% [6]
Synonyms:zhb-3082::Tn10, zhd-3082::Tn10

zhf-3084::Tn10

Linked marker

CAG18456 = CGSC7576[5]

est. P1 cotransduction: 1% [6]
Synonyms:zhe-3084::Tn10nnnCAG18456 also carries cysG0 (CGSC).

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11268

EchoBASE (EcoliWiki Page)

EchoBASE:EB1247

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b3288

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C4048

EcoGene (EcoliWiki Page)

EcoGene:EG11268

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:FMT

CGSC (EcoliWiki Page)

CGSC:33616

ASAP (EcoliWikiPage)

ASAP:ABE-0010781


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Fmt

Synonyms

10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase[1], B3288[2][1], Ftm[2][1], YhdD[2][1], Fmt[2][1]

Product description

10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase[2][3]

Methionyl-tRNA formyltransferase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0016742

hydroxymethyl-, formyl- and related transferase activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002376
InterPro:IPR005793

F

Seeded from EcoCyc [7]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [7]

complete

GO:0009058

biosynthetic process

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002376
InterPro:IPR005793

P

Seeded from EcoCyc [7]

complete

GO:0008168

methyltransferase activity

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001555
SP_KW:KW-0489

F

Seeded from EcoCyc [7]

complete

GO:0006412

translation

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001555
InterPro:IPR005794
SP_KW:KW-0648
HAMAP:MF_00182

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0004479

methionyl-tRNA formyltransferase activity

GO_REF:0000002
GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR005794
EC:2.1.2.9
HAMAP:MF_00182

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011034

F

Seeded from EcoCyc [7]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009451

RNA modification

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

rfaP

PMID:16606699

Experiment(s):EBI-1145369

Protein

rpsG

PMID:16606699

Experiment(s):EBI-1145369

Protein

rplQ

PMID:16606699

Experiment(s):EBI-1145369

Protein

rplA

PMID:16606699

Experiment(s):EBI-1145369

Protein

rpsM

PMID:16606699

Experiment(s):EBI-1145369

Protein

ydfK

PMID:16606699

Experiment(s):EBI-1145369

Protein

rplD

PMID:16606699

Experiment(s):EBI-1145369

Protein

rpsI

PMID:16606699

Experiment(s):EBI-1145369

Protein

rpsD

PMID:16606699

Experiment(s):EBI-1145369, EBI-1145434

Protein

ynaE

PMID:16606699

Experiment(s):EBI-1145369

Protein

rplI

PMID:16606699

Experiment(s):EBI-1145369

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSESLRIIFA GTPDFAARHL DALLSSGHNV VGVFTQPDRP AGRGKKLMPS PVKVLAEEKG
LPVFQPVSLR PQENQQLVAE LQADVMVVVA YGLILPKAVL EMPRLGCINV HGSLLPRWRG
AAPIQRSLWA GDAETGVTIM QMDVGLDTGD MLYKLSCPIT AEDTSGTLYD KLAELGPQGL
ITTLKQLADG TAKPEVQDET LVTYAEKLSK EEARIDWSLS AAQLERCIRA FNPWPMSWLE
IEGQPVKVWK ASVIDTATNA APGTILEANK QGIQVATGDG ILNLLSLQPA GKKAMSAQDL
LNSRREWFVP GNRLV
Length

315

Mol. Wt

34.168 kDa

pI

5.5 (calculated)

Extinction coefficient

44,460 - 44,835 (calc based on 4 Y, 7 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed

UniProt:P23882


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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11268-MONOMER

UniProt (EcoliWiki Page)

UniProt:P23882

PFAM (EcoliWiki Page)

PFAM:PF00551

RefSeq (EcoliWiki Page)

RefSeq:NP_417746


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

def-fmt

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=3432216..3432256&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b3288 (EcoliWiki Page)

NCBI GEO profiles for fmt

microarray

GenExpDB:b3288 (EcoliWiki Page)

Summary of data for fmt from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to fmt Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11268

EchoBASE (EcoliWiki Page)

EchoBASE:EB1247

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b3288

EcoGene (EcoliWiki Page)

EcoGene:EG11268


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Anopheles gambiae

  • ENSANGP00000022001 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT1G66520 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0039836 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Oryza gramene

  • Q5N7L5 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000009141 (score: 1.000; bootstrap: 75%)
  • ENSPTRP00000026424 (score: 0.640)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YBL013W (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPAC18059c (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

FMT

From SHIGELLACYC

E. coli O157

FMT

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00551


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

Categories

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