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folA:Gene Product(s)
From EcoliWiki
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
FolA |
|---|---|
| Synonyms |
dihydrofolate reductase[1], B0048[2][1], Tmr[2][1], TmrA[2][1], FolA[2][1] |
| Product description |
Dihydrofolate reductase; trimethoprim resistance[4] |
| EC number (for enzymes) | |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0050661 |
NADP or NADPH binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0046677 |
response to antibiotic |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0031427 |
response to methotrexate |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0009165 |
nucleotide biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006730 |
one-carbon metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006545 |
glycine biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0004146 |
dihydrofolate reductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0005737 |
cytoplasm |
C |
Seeded from Riley et al 2006 [1]. |
required fields missing | ||||
| GO:0055114 |
oxidation reduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0046656 |
folic acid biosynthetic process |
P |
Seeded from EcoCyc 11.1[3]. |
required field missing | ||||
| GO:0009257 |
10-formyltetrahydrofolate biosynthetic process |
|
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc 11.1[3]. Table 2 shows the results of assays performed using dihydrofolate as a substrate for the synthesis of tetrahydrofolate in the presence of NADPH. |
complete | ||
| GO:0042493 |
response to drug |
IDA: Inferred from Direct Assay |
P |
Trimethoprim |
complete | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Experiment(s):EBI-1135444 | |||
|
Protein |
Experiment(s):EBI-1135444 | |||
|
Protein |
Experiment(s):EBI-1135444 | |||
|
Protein |
Experiment(s):EBI-1135444 | |||
|
Protein |
Experiment(s):EBI-891656 | |||
|
Protein |
Experiment(s):EBI-891656 | |||
|
Protein |
Experiment(s):EBI-891656 | |||
|
Protein |
Experiment(s):EBI-891656 | |||
|
Protein |
Experiment(s):EBI-891656 | |||
|
Protein |
Experiment(s):EBI-891656 | |||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Source | Notes |
|---|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MISLIAALAV DRVIGMENAM PWNLPADLAW FKRNTLNKPV IMGRHTWESI GRPLPGRKNI ILSSQPGTDD RVTWVKSVDE AIAACGDVPE IMVIGGGRVY EQFLPKAQKL YLTHIDAEVE GDTHFPDYEP DDWESVFSEF HDADAQNSHS YCFEILERR |
|---|---|
| Length |
159 |
| Mol. Wt |
17.999 kDa |
| pI |
4.7 (calculated) |
| Extinction coefficient |
33,460 - 33,710 (calc based on 4 Y, 5 W, and 2 C residues) |
| edit table |
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
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|
Structure
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Structure figures
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| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ 6.0 6.1 Rood JI et al. (1980) Cloning of the Escherichia coli K-12 dihydrofolate reductase gene following mu-mediated transposition. Gene 8: 255-65 PubMed EcoliWiki page
- ↑ 7.0 7.1 7.2 7.3 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page
