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Standard Name


Gene Synonym(s)

ECK3496, b3512, JW3480, yhiE, yhiT[1], yhiT

Product Desc.

GadE transcriptional activator[2][3]

Transcriptional regulator of the gadABC operon[4]

Product Synonyms(s)

DNA-binding transcriptional activator[1], B3512[2][1], YhiT[2][1], YhiE[2][1], GadE[2][1], acid-responsive regulator of gadA and gadBC[2][1] , ECK3496, JW3480, yhiE, yhiT, b3512

Function from GO
Knock-Out Phenotype

Sensitive to pH below pH 2.5


transcription unit(s): gadE[2]


Activated by EvgA, YdeO, GadX, GadW, GadE, MnmE(indirect?)

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GadE overexpression confers acid resistance. GadE is induced by YdeO overexpression. GadE is in the EvgAS regulon. GadE is a LuxR family regulator. GadE is possibly involved in the regulation of type III secretion systems in enterohemorrhagic E. coli O157:H7. Required for stationary phase-induced, pH 5.5 growth medium-induced, and EvgA-induced acid resistance[4]


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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.