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gfcC:On One Page

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Quickview | Gene | Product(s) | Expression| Evolution | References |

Quickview

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See Help:Quickview for help with entering information in the Quickview table.

Standard Name

gfcC

Gene Synonym(s)

ymcB, ECK0976, b0985, JW0968[1][2][3]

Product Desc.

conserved protein[3][2]

Required for formation of the O-antigen capsule; silenced by IS1D insertion in promoter region[4]

Product Synonyms(s)

conserved protein[1], B0985[3][1], YmcB[3][1], GfcC[3][1]

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ymcA[3]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(gfcC)    Textpresso(gfcC)

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Notes

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Function characterized in enteropathogenic E. coli (EPEC). Part of the gfcABCDE-etp-etk operon. gfcC and yjbG are paralogs. First 22 aa predicted to be a type I signal peptide.[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

gfcC

Mnemonic

Group 4 Capsule

Synonyms

ymcB, ECK0976, b0985, JW0968[1][2][3]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

22.57 minutes 

MG1655: 1047914..1047168
gbrowse_img.php?coord=1047168..1047914&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 1065036..1065782
gbrowse_img.php?coord=1065036..1065782&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 1049113..1048367
gbrowse_img.php?coord=1048367..1049113&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 1101842..1101096
gbrowse_img.php?coord=1101096..1101842&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 950136..950882
gbrowse_img.php?coord=950136..950882&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔgfcC729::kan

PMID:16738554

CGSC:106194


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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

Plasmid clone

Shigen

PMID:16769691

Status:

Primer 1:

Primer 2:

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G6506

EchoBASE (EcoliWiki Page)

EchoBASE:EB3494

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0985

EcoGene (EcoliWiki Page)

EcoGene:EG13730

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:YMCB

ASAP (EcoliWikiPage)

ASAP:ABE-0003321


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

YmcB

Synonyms

conserved protein[1], B0985[3][1], YmcB[3][1], GfcC[3][1]

Product description

conserved protein[3][2]

Required for formation of the O-antigen capsule; silenced by IS1D insertion in promoter region[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MNKLQSYFIA SVLYVMTPHA FAQGTVTIYL PGEQQTLSVG PVENVVQLVT QPQLRDRLWW
PGALLTDSAA KAKALKDYQH VMAQLASWEA EADDDVAATI KSVRQQLLNL NITGRLPVKL
DPDFVRVDEN SNPPLVGDYT LYTVQRPVTI TLLGAVSGAG QLPWQAGRSV TDYLQDHPRL
AGADKNNVMV ITPEGETVVA PVALWNKRHV EPPPGSQLWL GFSAHVLPEK YADLNDQIVS
VLTQRVPD
Length

248

Mol. Wt

27.295 kDa

pI

5.3 (calculated)

Extinction coefficient

44,920 (calc based on 8 Y, 6 W, and C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

motif

1-22

UniProt Manual:Signal Peptides

UniProt:P75883


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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G6506-MONOMER

UniProt (EcoliWiki Page)

UniProt:P75883

PFAM (EcoliWiki Page)

PFAM:PF06251

RefSeq (EcoliWiki Page)

RefSeq:NP_415505


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

ymcA

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File:.jpg

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=1047894..1047934&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein+flip&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b0985 (EcoliWiki Page)

NCBI GEO profiles for gfcC

microarray

GenExpDB:b0985 (EcoliWiki Page)

Summary of data for gfcC from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to gfcC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G6506

EchoBASE (EcoliWiki Page)

EchoBASE:EB3494

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0985

EcoGene (EcoliWiki Page)

EcoGene:EG13730


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Shigella flexneri

YMCB

From SHIGELLACYC

E. coli O157

YMCB

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF06251


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.

Categories

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