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Standard Name


Gene Synonym(s)

ECK2550, b2553, JW2537[1], JW2537

Product Desc.

PII[2][3], PII-UMP[2][3],

Component of PII[2][3]

PII regulatory protein for glutamine synthase; potent activator of NRII/GlnL/NtrB phosphatase and inhibitor of NRII autophosphorylation; activates adenylation of GlnA by GlnE[4]

Product Synonyms(s)

regulatory protein P-II for glutamine synthetase[1], B2553[2][1],[protein PII][2], uridylyl-[protein PII][2][1] , ECK2550, JW2537, b2553

Function from GO
Knock-Out Phenotype

transcription unit(s): glnB[2], OP00126

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GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. In nitrogen limitation GlnB is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. GlnB interacts with and regulates the activities of the histidine protein kinase NtrB, which controls phosphorylation of NtrC. It also regulates the activity of adenylyltransferase (GlnE) which in turn regulates the activity of glutamine synthetase (GlnA). glnK is a glnB paralog. [Comment provided by EcoTeam member Mike Merrick, 11.16.06][4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.