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Standard Name

gpmA

Gene Synonym(s)

ECK0744, b0755, JW0738, gpm[1]

Product Desc.

phosphoglyceromutase 1[2][3];

Component of phosphoglyceromutase 1[2][3]

Phosphoglycerate mutase 1, 2,3-bisphosphoglycerate-dependent; Fur regulon; dimeric[4]

Product Synonyms(s)

phosphoglyceromutase 1[1], B0755[2][1], Gpm[2][1], GpmA[2][1]

Function from GO

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): gpmA[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(gpmA)    Textpresso(gpmA)

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Notes

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HT_Cmplx25_Cyt: GpmA+GpmM.[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

gpmA

Mnemonic

Glycerol P mutase

Synonyms

ECK0744, b0755, JW0738, gpm[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

16.94 minutes 

MG1655: 786818..786066
gbrowse_img.php?coord=786066..786818&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 768224..767472
gbrowse_img.php?coord=767472..768224&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 788017..787265
gbrowse_img.php?coord=787265..788017&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 839410..838658
gbrowse_img.php?coord=838658..839410&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 689034..689786
gbrowse_img.php?coord=689034..689786&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔgpmA (Keio:JW0738)

deletion

deletion

PMID:16738554

Shigen

gpmA

PMID:12519969

ASAP

At position 160 in Plus orientation, does not contain plasmid pKD46.
ASAP strain name: FB20230

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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW0738

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCGCTGTAACTAAGCTGGTTCT

Primer 2:CCCTTCGCTTTACCCTGGTTTGC

nadA57::Tn10

Linked marker

CAG12147 = CGSC7351[5]

est. P1 cotransduction: 80% [6]

zbh-29::Tn10

Linked marker

CAG18493 = CGSC7353[5]

est. P1 cotransduction: 24% [6]
Synonyms:zbi-29::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11699

EchoBASE (EcoliWiki Page)

EchoBASE:EB1650

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0755

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C0831

EcoGene (EcoliWiki Page)

EcoGene:EG11699

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:GPMA

CGSC (EcoliWiki Page)

CGSC:35790

ASAP (EcoliWikiPage)

ASAP:ABE-0002563


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

GpmA

Synonyms

phosphoglyceromutase 1[1], B0755[2][1], Gpm[2][1], GpmA[2][1]

Product description

phosphoglyceromutase 1[2][3];

Component of phosphoglyceromutase 1[2][3]

Phosphoglycerate mutase 1, 2,3-bisphosphoglycerate-dependent; Fur regulon; dimeric[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0005737

cytoplasm

PMID:16858726

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [7]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001345

F

Seeded from EcoCyc [7]

complete

GO:0004619

phosphoglycerate mutase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:5.4.2.1

F

Seeded from EcoCyc [7]

complete

GO:0006096

glycolysis

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR005952
SP_KW:KW-0324
HAMAP:MF_01039

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001345

P

Seeded from EcoCyc [7]

complete

GO:0016853

isomerase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0413

F

Seeded from EcoCyc [7]

complete

GO:0016868

intramolecular transferase activity, phosphotransferases

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005952

F

Seeded from EcoCyc [7]

complete

GO:0046538

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01039

F

Seeded from EcoCyc [7]

complete

GO:0006094

gluconeogenesis

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016052

carbohydrate catabolic process

P

required field missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of phosphoglyceromutase 1

could be indirect

Protein

rpmB

PMID:16606699

Experiment(s):EBI-1137861

Protein

livK

PMID:16606699

Experiment(s):EBI-1137861

Protein

pepD

PMID:16606699

Experiment(s):EBI-1137861

Protein

aroG

PMID:16606699

Experiment(s):EBI-1137861

Protein

thrS

PMID:16606699

Experiment(s):EBI-1137861

Protein

aslA

PMID:16606699

Experiment(s):EBI-1137861

Protein

purC

PMID:16606699

Experiment(s):EBI-1137861

Protein

nadE

PMID:16606699

Experiment(s):EBI-1137861

Protein

mlc

PMID:16606699

Experiment(s):EBI-1137861

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MAVTKLVLVR HGESQWNKEN RFTGWYDVDL SEKGVSEAKA AGKLLKEEGY SFDFAYTSVL
KRAIHTLWNV LDELDQAWLP VEKSWKLNER HYGALQGLNK AETAEKYGDE QVKQWRRGFA
VTPPELTKDD ERYPGHDPRY AKLSEKELPL TESLALTIDR VIPYWNETIL PRMKSGERVI
IAAHGNSLRA LVKYLDNMSE EEILELNIPT GVPLVYEFDE NFKPLKRYYL GNADEIAAKA
AAVANQGKAK
Length

250

Mol. Wt

28.556 kDa

pI

5.7 (calculated)

Extinction coefficient

56,380 (calc based on 12 Y, 7 W, and C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed

UniProt:P62707


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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:GPMA-MONOMER

UniProt (EcoliWiki Page)

UniProt:P62707

PFAM (EcoliWiki Page)

PFAM:PF00300

RefSeq (EcoliWiki Page)

RefSeq:NP_415276


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

gpmA

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=786798..786838&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein+flip&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b0755 (EcoliWiki Page)

NCBI GEO profiles for gpmA

microarray

GenExpDB:b0755 (EcoliWiki Page)

Summary of data for gpmA from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to gpmA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11699

EchoBASE (EcoliWiki Page)

EchoBASE:EB1650

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0755

EcoGene (EcoliWiki Page)

EcoGene:EG11699


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Anopheles gambiae

  • ENSANGP00000015800 (score: 1.000; bootstrap: 98%)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000005507 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT1G22170 (score: 1.000; bootstrap: 100%)
  • AT1G78050 (score: 0.632)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000016874 (score: 1.000; bootstrap: 97%)
  • ENSBTAP00000019336 (score: 0.585)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000013328 (score: 1.000; bootstrap: 97%)
  • ENSCAFP00000004259 (score: 0.567)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000016603 (score: 1.000; bootstrap: 100%)
  • ENSCINP00000008164 (score: 0.487)

From Inparanoid:20070104

Danio rerio

  • ZDB-CDNA-040425-652 (score: 1.000; bootstrap: 93%)
  • ZDB-GENE-030131-1827 (score: 1.000; bootstrap: 94%)
  • ZDB-CDNA-040425-653 (score: 1.000; bootstrap: 94%)
  • ZDB-CDNA-040425-1299 (score: 0.869)
  • ZDB-GENE-030131-5376 (score: 0.869)
  • ZDB-GENE-040519-1 (score: 0.752)
  • ZDB-CDNA-040425-654 (score: 0.575)
  • ZDB-GENE-040116-6 (score: 0.575)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0231354 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0014869 (score: 1.000; bootstrap: 99%)
  • FBgn0011270 (score: 0.512)

From Inparanoid:20070104

Drosophila pseudoobscura

  • GA14392-PA (score: 1.000; bootstrap: 99%)
  • GA14593-PA (score: 0.477)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000021309 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000351067 (score: 1.000; bootstrap: 96%)
  • ENSP00000306191 (score: 1.000; bootstrap: 96%)
  • ENSP00000348237 (score: 0.986)
  • ENSP00000334304 (score: 0.889)
  • ENSP00000348804 (score: 0.889)
  • ENSP00000297283 (score: 0.597)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000026333 (score: 1.000; bootstrap: 97%)
  • ENSMMUP00000013841 (score: 0.653)
  • ENSMMUP00000003245 (score: 0.588)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000005228 (score: 1.000; bootstrap: 99%)
  • ENSMODP00000017399 (score: 0.580)
  • ENSMODP00000022556 (score: 0.384)
  • ENSMODP00000015821 (score: 0.155)

From Inparanoid:20070104

Mus musculus

  • MGI:3645709 (score: 1.000; bootstrap: 97%)
  • MGI:3643310 (score: 1.000; bootstrap: 97%)
  • MGI:97552 (score: 0.991)
  • MGI:1933118 (score: 0.548)

From Inparanoid:20070104

Oryza gramene

  • Q67UJ0 (score: 1.000; bootstrap: 100%)
  • Q6Z8J0 (score: 0.643)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000032683 (score: 1.000; bootstrap: 93%)
  • ENSPTRP00000004915 (score: 0.187)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000018227 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YKL152C (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPAC26F16 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000143399 (score: 1.000; bootstrap: 95%)
  • NEWSINFRUP00000153098 (score: 0.715)
  • NEWSINFRUP00000182800 (score: 0.491)
  • NEWSINFRUP00000181195 (score: 0.056)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00026289001 (score: 1.000; bootstrap: 97%)
  • GSTENP00016506001 (score: 0.750)
  • GSTENP00011651001 (score: 0.509)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000049101 (score: 1.000; bootstrap: 76%)
  • ENSXETP00000039940 (score: 0.578)

From Inparanoid:20070104

Shigella flexneri

GPMA

From SHIGELLACYC

E. coli O157

GPMA

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00300


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

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