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guaA:Gene Product(s)
From EcoliWiki
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
GuaA |
|---|---|
| Synonyms |
GMP synthetase (glutamine aminotransferase)[1], B2507[2][1], GuaA[2][1] |
| Product description |
Component of GMP-SYN-CPLX[2] GMP synthase[4] |
| EC number (for enzymes) | |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003922 |
GMP synthase (glutamine-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0003921 |
GMP synthase activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0003922 |
GMP synthase (glutamine-hydrolyzing) activity |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001674 |
F |
Seeded from EcoCyc 12.5 [6] |
complete | ||
| GO:0004808 |
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001674 |
F |
Seeded from EcoCyc 12.5 [6] |
complete | ||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [8] |
complete | |||
| GO:0006177 |
GMP biosynthetic process |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001674 |
P |
Seeded from EcoCyc 12.5 [6] |
complete | ||
| GO:0006541 |
glutamine metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0008033 |
tRNA processing |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0006177 |
GMP biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000991 |
F |
Seeded from EcoCyc [8] |
complete | ||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc [8] |
complete | |||
| GO:0009058 |
biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0016874 |
ligase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0015949 |
nucleobase, nucleoside and nucleotide interconversion |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0003922 |
GMP synthase (glutamine-hydrolyzing) activity |
IDA |
F |
Seeded from EcoCyc 11.1[3]. |
required fields missing | |||
| GO:0006177 |
GMP biosynthetic process |
IMP |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | |||
| GO:0003921 |
GMP synthase activity |
IDA |
F |
Seeded from EcoCyc 11.1[3]. |
required fields missing | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of GMP-SYN-CPLX |
could be indirect | ||
|
Protein |
Experiment(s):EBI-1143063 | |||
|
Protein |
Experiment(s):EBI-1143063 | |||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Source | Notes |
|---|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MTENIHKHRI LILDFGSQYT QLVARRVREL GVYCELWAWD VTEAQIRDFN PSGIILSGGP ESTTEENSPR APQYVFEAGV PVFGVCYGMQ TMAMQLGGHV EASNEREFGY AQVEVVNDSA LVRGIEDALT ADGKPLLDVW MSHGDKVTAI PSDFITVAST ESCPFAIMAN EEKRFYGVQF HPEVTHTRQG MRMLERFVRD ICQCEALWTP AKIIDDAVAR IREQVGDDKV ILGLSGGVDS SVTAMLLHRA IGKNLTCVFV DNGLLRLNEA EQVLDMFGDH FGLNIVHVPA EDRFLSALAG ENDPEAKRKI IGRVFVEVFD EEALKLEDVK WLAQGTIYPD VIESAASATG KAHVIKSHHN VGGLPKEMKM GLVEPLKELF KDEVRKIGLE LGLPYDMLYR HPFPGPGLGV RVLGEVKKEY CDLLRRADAI FIEELRKADL YDKVSQAFTV FLPVRSVGVM GDGRKYDWVV SLRAVETIDF MTAHWAHLPY DFLGRVSNRI INEVNGISRV VYDISGKPPA TIEWE |
|---|---|
| Length |
525 |
| Mol. Wt |
58.678 kDa |
| pI |
5.2 (calculated) |
| Extinction coefficient |
64,860 - 65,735 (calc based on 14 Y, 8 W, and 7 C residues) |
| edit table |
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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
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Structure
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Structure figures
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| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Deras ML et al. (1999) N2-hydroxyguanosine 5'-monophosphate is a time-dependent inhibitor of Escherichia coli guanosine monophosphate synthetase. Biochemistry 38: 303-10 PubMed EcoliWiki page
- ↑ 6.0 6.1 6.2 6.3 6.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 7.0 7.1 Abbott JL et al. (2006) The effects of removing the GAT domain from E. coli GMP synthetase. Protein J 25: 483-91 PubMed EcoliWiki page
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ 9.0 9.1 9.2 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
- ↑ 10.0 10.1 Lambden PR & Drabble WT (1973) The gua operon of Escherichia coli K-12: evidence for polarity from guaB to guaA. J Bacteriol 115: 992-1002 PubMed EcoliWiki page
- ↑ Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed EcoliWiki page
- ↑ Macek B et al. (2007) Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol Cell Proteomics PubMed EcoliWiki page
