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gyrA:Gene Product(s)
From EcoliWiki
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
| Standard name |
GyrA product |
|---|---|
| Synonyms |
DNA gyrase (type II topoisomerase), subunit A product[1], B2231 product[2][1], ParD product[2][1], NorA product[2][1], NfxA product[2][1], NalA product[2][1], HisW product[2][1], GyrA product[2][1] |
| Product description |
Component of ; DNA gyrase[3] |
| EC number (for enzymes) | |
| edit table |
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0003916 |
DNA topoisomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0005524 |
ATP binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0005694 |
chromosome |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
C |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0006265 |
DNA topological change |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
P |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0006268 |
DNA unwinding during replication |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0016853 |
isomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0046677 |
response to antibiotic |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0005624 |
membrane fraction |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0006261 |
DNA-dependent DNA replication |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0006350 |
transcription |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0042493 |
response to drug |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| edit table |
Interactions
| Partner Type | Partner | Notes | References |
|---|---|---|---|
|
Protein |
Subunits of DNA gyrase |
could be indirect |
|
| edit table |
See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Notes
Localization
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
| edit table |
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Notes
Structure and Physical Properties
Physical Properties
| Sequence |
MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMNVLGNDWN KAYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFSLRY MLVDGQGNFG SIDGDSAAAM RYTEIRLAKI AHELMADLEK ETVDFVDNYD GTEKIPDVMP TKIPNLLVNG SSGIAVGMAT NIPPHNLTEV INGCLAYIDD EDISIEGLME HIPGPDFPTA AIINGRRGIE EAYRTGRGKV YIRARAEVEV DAKTGRETII VHEIPYQVNK ARLIEKIAEL VKEKRVEGIS ALRDESDKDG MRIVIEVKRD AVGEVVLNNL YSQTQLQVSF GINMVALHHG QPKIMNLKDI IAAFVRHRRE VVTRRTIFEL RKARDRAHIL EALAVALANI DPIIELIRHA PTPAEAKTAL VANPWQLGNV AAMLERAGDD AARPEWLEPE FGVRDGLYYL TEQQAQAILD LRLQKLTGLE HEKLLDEYKE LLDQIAELLR ILGSADRLME VIREELELVR EQFGDKRRTE ITANSADINL EDLITQEDVV VTLSHQGYVK YQPLSEYEAQ RRGGKGKSAA RIKEEDFIDR LLVANTHDHI LCFSSRGRVY SMKVYQLPEA TRGARGRPIV NLLPLEQDER ITAILPVTEF EEGVKVFMAT ANGTVKKTVL TEFNRLRTAG KVAIKLVDGD ELIGVDLTSG EDEVMLFSAE GKVVRFKESS VRAMGCNTTG VRGIRLGEGD KVVSLIVPRG DGAILTATQN GYGKRTAVAE YPTKSRATKG VISIKVTERN GLVVGAVQVD DCDQIMMITD AGTLVRTRVS EISIVGRNTQ GVILIRTAED ENVVGLQRVA EPVDEEDLDT IDGSAAEGDD EIAPEVDVDD EPEEE |
|---|---|
| Mol. Wt |
96.96 kDa (calc) [2] |
| pI | |
| Extinction coefficient |
52260 - 52760 (calc based on 24 Y, 3 W, and 4 C residues) |
| edit table |
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Domains/Motifs/Modification Sites
| Type | Residues | Description | Notes |
|---|---|---|---|
| edit table |
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
Structure
| Structures |
|
|---|---|
| Models |
View models at: |
| edit table |
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
Notes
Gene Product Resources
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Notes
Accessions in Other Databases
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
See Help:Product_accessions for help entering or editing information in this section of EcoliWiki.
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 5.0 5.1 Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed EcoliWiki page
- ↑ Chao L & Tillman DM (1982) Enhanced resistance to nitrosoguanidine killing and mutagenesis in a DNA gyrase mutant of Escherichia coli. J Bacteriol 151: 764-70 PubMed EcoliWiki page
Categories
Categories: GO:0003677 ! DNA binding | GO:0003916 ! DNA topoisomerase activity | GO:0003918 ! DNA topoisomerase (ATP-hydrolyzing) activity | GO:0005524 ! ATP binding | GO:0005694 ! chromosome | GO:0006265 ! DNA topological change | GO:0006268 ! DNA unwinding during replication | GO:0016853 ! isomerase activity | GO:0046677 ! response to antibiotic | GO:0005624 ! membrane fraction | GO:0005737 ! cytoplasm | GO:0006261 ! DNA-dependent DNA replication | GO:0006350 ! transcription | GO:0042493 ! response to drug | Proteins | Complex:DNA gyrase | Products with structures in PDB
