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Standard Name


Gene Synonym(s)

ECK4171, b4175, JW4133, hflA[1], hflA

Product Desc.

regulator of FtsH protease[2][3];

Component of HflK-HflC complex; regulator of FtsH protease[3]; HflB, integral membrane ATP-dependent zinc metallopeptidase[3]

Membrane bound protease complex, with FtsH and HflK; regulates lysogeny; non-essential[4]

Product Synonyms(s)

modulator for HflB protease specific for phage lambda cII repressor[1], B4175[2][1], HflA[2][1], HflC[2][1] , ECK4171, hflA, JW4133, b4175

Function from GO
Knock-Out Phenotype

transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC

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Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. Null hflC or hflK alleles stabilize cytoplasmic substrate cII. hflCK is a multicopy suppressor of ftsH htpX double mutant. Serine protease-like motif in HflC not required for cII degradation. HflC and HflK have a periplasmic prohibitin homology (PHB) domain. HT_Cmplx45_Mem: HflC+HybC+BamB.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.