PortEco logo


From EcoliWiki
(Redirected from hfq)
Jump to: navigation, search

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

Standard Name


Gene Synonym(s)

ECK4168, b4172, JW4130, HF-I, HF-1[1][2]

Product Desc.

RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins[2][3];

Component of HF-I, host factor for RNA phage Q β replication[3]

Global regulator of sRNA function; host factor for RNA phage Q beta replication; HF-I; DNA- and RNA-binding protein; RNA chaperone; multiple regulatory roles: destabilzes ompA mRNA, improves rpoS translation, sRNA DsrA co-factor; binds RNAP; ATPase[4]

Product Synonyms(s)

HF-I, host factor for RNA phage Q beta replication[1], B4172[2][1], Hfq[2][1], HF-I[2][1], host factor I[2][1] , ECK4168, JW4130, b4172

Function from GO

Biological Process

Molecular Function

Knock-Out Phenotype

transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

See Help:Quickview for help with entering information in the Quickview table.


[back to top]

The C-terminal of Hfq is not necessary for hexamerization. RNA binding is located primarily at the N-terminal. Hfq has intrinsic ATPase activity (Sukhodolets, 2003; Arluison, 2007).[4]

Hfq enhances RNA-RNA pairing. [5]


[back to top]

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Zhang, A et al. (2002) The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs. Mol. Cell 9 11-22 PubMed EcoliWiki page