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hslV:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HslV

Synonyms

peptidase component of the HslUV protease[1], B3932[2][1], ClpQ[2][1], YiiC[2][1], HtpO[2][1], HslV[2][1]

Product description

peptidase component of the HslVU protease[2][3];

Component of HslV hexamer[3]; HslVU protease[3]

Heat-inducible ATP-dependent protease HslVU, protease subunit; involved in the degradation of misfolded proteins[4]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0004298

threonine-type endopeptidase activity

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001353
SP_KW:KW-0888

F

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0005839

proteasome core complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001353

C

Seeded from EcoCyc [5]

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001353

P

Seeded from EcoCyc [5]

complete

GO:0006950

response to stress

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc [5]

complete

GO:0008233

peptidase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc [5]

complete

GO:0005829

cytosol

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [5]

complete

GO:0006508

proteolysis

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0006457

protein folding

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009050

glycopeptide catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0000910

cytokinesis

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009408

response to heat

PMID:8349564[8]

IEP: Inferred from Expression Pattern

P

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of HslV hexamer

could be indirect

Protein

deaD

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

hslU

PMID:15690043[9]

Experiment(s):EBI-880750, EBI-886932

Protein

rplB

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

tpiA

PMID:16606699[10]

Experiment(s):EBI-1147088

Protein

rplC

PMID:15690043[9]

Experiment(s):EBI-880750, EBI-886859

Protein

yggN

PMID:16606699[10]

Experiment(s):EBI-1147088

Protein

rplD

PMID:15690043[9]

Experiment(s):EBI-880750, EBI-886859

Protein

yghT

PMID:16606699[10]

Experiment(s):EBI-1147088

Protein

rplI

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

prs

PMID:16606699[10]

Experiment(s):EBI-1147088

Protein

rplJ

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

rplQ

PMID:16606699[10]

Experiment(s):EBI-1147088

Protein

rplS

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

rplV

PMID:15690043[9]

Experiment(s):EBI-880750, EBI-886859

Protein

rpsG

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

rpsM

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

tufA

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

rluB

PMID:15690043[9]

Experiment(s):EBI-880750

Protein

accA

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

accB

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

accC

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

accD

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

ccmB

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

gabP

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

rplL

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

rplU

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

rplX

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

rpmC

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

rpmG

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

rpsP

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

yihI

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

yhjD

PMID:15690043[9]

Experiment(s):EBI-886859

Protein

Subunits of HslVU protease

could be indirect


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MTTIVSVRRN GHVVIAGDGQ ATLGNTVMKG NVKKVRRLYN DKVIAGFAGG TADAFTLFEL
FERKLEMHQG HLVKAAVELA KDWRTDRMLR KLEALLAVAD ETASLIITGN GDVVQPENDL
IAIGSGGPYA QAAARALLEN TELSAREIAE KALDIAGDIC IYTNHFHTIE ELSYKA
Length

176

Mol. Wt

19.092 kDa

pI

6.4 (calculated)

Extinction coefficient

11,460 - 11,585 (calc based on 4 Y, 1 W, and 1 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed (Probable)

UniProt:P0A7B8



rectanglemotifs

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11676-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A7B8

PFAM (EcoliWiki Page)

PFAM:PF00227

RefSeq (EcoliWiki Page)

RefSeq:NP_418367


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. 6.0 6.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed EcoliWiki page
  8. Chuang SE & Blattner FR (1993) Characterization of twenty-six new heat shock genes of Escherichia coli. J Bacteriol 175: 5242-52 PubMed EcoliWiki page
  9. 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 9.18 9.19 9.20 9.21 9.22 9.23 9.24 9.25 9.26 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page
  10. 10.0 10.1 10.2 10.3 10.4 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page

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