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Standard Name


Gene Synonym(s)

ECK2721, b2726, JW2696[1], JW2696

Product Desc.

accessory protein for nickel incorporation into hydrogenase 3[2][3];

Component of HypA-HypB heterodimer[3]

Hydrogenase 3 accessory protein required for activity[4]

Product Synonyms(s)

protein involved in nickel insertion into hydrogenases 3[1], B2726[2][1], HypA[2][1] , ECK2721, JW2696, b2726

Function from GO
Knock-Out Phenotype

transcription unit(s): hypABCDE-fhlA[2], hypABCDE[2], OP00209, hydBEF

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hypA mutants have increased Hydrogenase 2 activity but similar amounts of HypA protein. hypA defect suppressed by expression of hypB-E under foreign promoter, indicating a regulatory or partially redundant function. Paralogous to hybF.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.